Chronic kidney disease and pregnancy outcomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10434398" target="_blank" >RIV/00216208:11110/21:10434398 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/21:10434398

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=osEb4e7lW3" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=osEb4e7lW3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-021-00670-3" target="_blank" >10.1038/s41598-021-00670-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chronic kidney disease and pregnancy outcomes

Popis výsledku v původním jazyce

Pregnancy complicated by CKD is currently not fully understood topic. Outcome of pregnancy in patients with CKD is related to impaired glomerular filtration rate and the degree of proteinuria. In our study we evaluated the association of serum creatinine level and proteinuria with both maternal and fetal outcomes in the cohort of 84 pregnant patients with CKD. In CKD group we confirmed negative correlation of highest serum creatinine level in pregnancy to fetal weight (p value &lt; 0.001) and gestation period (p value &lt; 0.001). Likewise, negative correlation of preconception serum creatinine to fetal weight (p value &lt; 0.001) and gestation period (p value 0.002). Negative correlation of proteinuria to gestation period (p value &lt; 0.001) and fetal weight (p value &lt; 0.001) was also demonstrated. CKD is serious risk factor for pregnancy outcome. Proteinuria and serum creatinine level should be examined before pregnancy and regularly monitored during pregnancy. Higher serum creatinine levels and higher proteinuria predispose to shorter gestation period and lower birth weight of the neonate.

Název v anglickém jazyce

Chronic kidney disease and pregnancy outcomes

Popis výsledku anglicky

Pregnancy complicated by CKD is currently not fully understood topic. Outcome of pregnancy in patients with CKD is related to impaired glomerular filtration rate and the degree of proteinuria. In our study we evaluated the association of serum creatinine level and proteinuria with both maternal and fetal outcomes in the cohort of 84 pregnant patients with CKD. In CKD group we confirmed negative correlation of highest serum creatinine level in pregnancy to fetal weight (p value &lt; 0.001) and gestation period (p value &lt; 0.001). Likewise, negative correlation of preconception serum creatinine to fetal weight (p value &lt; 0.001) and gestation period (p value 0.002). Negative correlation of proteinuria to gestation period (p value &lt; 0.001) and fetal weight (p value &lt; 0.001) was also demonstrated. CKD is serious risk factor for pregnancy outcome. Proteinuria and serum creatinine level should be examined before pregnancy and regularly monitored during pregnancy. Higher serum creatinine levels and higher proteinuria predispose to shorter gestation period and lower birth weight of the neonate.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Reports

ISSN

2045-2322

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

21299

Kód UT WoS článku

000712891800028

EID výsledku v databázi Scopus

2-s2.0-85118444516