8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10436143" target="_blank" >RIV/00216208:11110/21:10436143 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/21:10436143

Výsledek na webu

<a href="https://doi.org/10.1515/9783110685701-014" target="_blank" >https://doi.org/10.1515/9783110685701-014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/9783110685701-014" target="_blank" >10.1515/9783110685701-014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging

Popis výsledku v původním jazyce

&quot;Classical&quot; magnetic resonance imaging (MRI) is based on imaging of water protons and the technique is commonly used in clinical and preclinical practice. The 19F nuclide has nuclear magnetic properties similar to those of 1H and can be used for MRI on common commercial scanners with only minor modifications. The 19F MRI is a potentially interesting tool for preclinical or even clinical imaging. As there is no abundance of 19F in a living body, 19F MRI requires contrast agents (CAs) containing fluorine atoms and is presented as &quot;hotspot&quot; imaging. In this text, we present how the current development of 19F MRI CAs is influenced by utilization of paramagnetic metal ions as relaxation agents through shortening the long 19F relaxation times. The theory behind the change of relaxation times is briefly introduced. Influence of lanthanide(III) and transition metal ions on the relaxation properties of the 19F nucleus in defined molecules and in nanoobjects is reviewed and differences between complexes of these two metal ion families are discussed. The 19F tracers are best utilized as responsive MRI CAs and various responsive modes of the probes are reviewed and evaluated. As 19F MRI requires some special consideration about acquisition techniques, the main differences between 1H and 19F MRI are discussed. Briefly, some outlook for the technique is suggested.

Název v anglickém jazyce

8 Paramagnetic Metal Ion Probes for 19F Magnetic Resonance Imaging

Popis výsledku anglicky

&quot;Classical&quot; magnetic resonance imaging (MRI) is based on imaging of water protons and the technique is commonly used in clinical and preclinical practice. The 19F nuclide has nuclear magnetic properties similar to those of 1H and can be used for MRI on common commercial scanners with only minor modifications. The 19F MRI is a potentially interesting tool for preclinical or even clinical imaging. As there is no abundance of 19F in a living body, 19F MRI requires contrast agents (CAs) containing fluorine atoms and is presented as &quot;hotspot&quot; imaging. In this text, we present how the current development of 19F MRI CAs is influenced by utilization of paramagnetic metal ions as relaxation agents through shortening the long 19F relaxation times. The theory behind the change of relaxation times is briefly introduced. Influence of lanthanide(III) and transition metal ions on the relaxation properties of the 19F nucleus in defined molecules and in nanoobjects is reviewed and differences between complexes of these two metal ion families are discussed. The 19F tracers are best utilized as responsive MRI CAs and various responsive modes of the probes are reviewed and evaluated. As 19F MRI requires some special consideration about acquisition techniques, the main differences between 1H and 19F MRI are discussed. Briefly, some outlook for the technique is suggested.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/LTC17067" target="_blank" >LTC17067: Využití NMR relaxačních a difúzních měření pro stanovení dynamiky komplexních molekulárních systémů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Metal Ions in Bio-Imaging Techniques

ISBN

978-3-11-068556-5

Počet stran výsledku

32

Strana od-do

239-270

Počet stran knihy

503

Název nakladatele

Walter de Gruyter GmbH

Místo vydání

Berlin, Boston

Kód UT WoS kapitoly

—