Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F23%3A10449837" target="_blank" >RIV/00216208:11110/23:10449837 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=mE6GP_8hp_" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=mE6GP_8hp_</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1753495X221133150" target="_blank" >10.1177/1753495X221133150</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease

Popis výsledku v původním jazyce

Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described. Methods: A cross-sectional survey was sent to women from ADTKD families. Results: Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy. Eighteen percent of ADTKD mothers had hypertension during pregnancy versus 12% in controls (p  =  0.54) and &gt;40% in comparative studies of chronic kidney disease in pregnancy. Eleven percent of births of ADTKD mothers were &lt;37 weeks versus 0 in controls (p &lt; 0.0001). Cesarean section occurred in 19% of pregnancies in affected women versus 38% of unaffected individuals (p  =  0.06). Only 12% of babies required a neonatal intensive care unit stay. Conclusions: ADTKD pregnancies had lower rates of hypertension during pregnancy versus other forms of chronic kidney disease, which may have contributed to good maternal and fetal outcomes.

Název v anglickém jazyce

Maternal health and pregnancy outcomes in autosomal dominant tubulointerstitial kidney disease

Popis výsledku anglicky

Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is an increasingly recognized cause of chronic kidney disease. ADTKD pregnancy outcomes have not previously been described. Methods: A cross-sectional survey was sent to women from ADTKD families. Results: Information was obtained from 85 afffected women (164 term pregnancies) and 23 controls (50 pregnancies). Only 16.5% of genetically affected women knew they had ADTKD during pregnancy. Eighteen percent of ADTKD mothers had hypertension during pregnancy versus 12% in controls (p  =  0.54) and &gt;40% in comparative studies of chronic kidney disease in pregnancy. Eleven percent of births of ADTKD mothers were &lt;37 weeks versus 0 in controls (p &lt; 0.0001). Cesarean section occurred in 19% of pregnancies in affected women versus 38% of unaffected individuals (p  =  0.06). Only 12% of babies required a neonatal intensive care unit stay. Conclusions: ADTKD pregnancies had lower rates of hypertension during pregnancy versus other forms of chronic kidney disease, which may have contributed to good maternal and fetal outcomes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Obstetric Medicine

ISSN

1753-495X

e-ISSN

1753-4968

Svazek periodika

16

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

162-169

Kód UT WoS článku

000870449300001

EID výsledku v databázi Scopus

2-s2.0-85140625235