Cancer-Associated Fibroblasts and Their Role in Cancer Progression

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F23%3A10455906" target="_blank" >RIV/00216208:11110/23:10455906 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/16833_2022_79" target="_blank" >https://doi.org/10.1007/16833_2022_79</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/16833_2022_79" target="_blank" >10.1007/16833_2022_79</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cancer-Associated Fibroblasts and Their Role in Cancer Progression

Popis výsledku v původním jazyce

Cancer incidence is increasing worldwide, partially due to the population ageing. This can be linked to advanced and accessible medical care. This trend represents a challenge for healthcare systems in many countries. Development of new diagnostic procedures and therapeutic approaches seems to be necessary for sensible care for therapeutically fragile elderly patients. The cancer microenvironment, especially cancer-associated fibroblasts, represents a promising target for therapeutic manipulation, which has not yet been fully exploited.The chapter summarises data about the origin, markers and biological properties of cancer-associated fibroblasts. The position of cancer-associated fibroblasts in the tumour cellular ecosystem has been established, and their influence on cancer cell proliferation, differentiation, migration and therapeutic resistance is widely recognised.Cancer-associated fibroblasts can potentially result from transition from a broad panel of cell types. The most relevant mechanism seems to be recruitment of normal tissue fibroblasts and mesenchymal stem cells. This is achieved by means of paracrine secretion from cancer cells or via secreted exosomes. CAFs are heterogeneous and represent a potent source of growth factors, pro-inflammatory cytokines, chemokines and also exosomes that significantly activate proliferation and migration of cancer cells.Cancer-associated fibroblasts represent a biologically potent and non-malignant population of cells in malignant tumours. CAF detection and phenotypic and functional characterisation in the distinct types of tumours can refine diagnostics. Moreover, CAFs are an available target for therapeutic interventions, which can potentially advance oncological therapy.

Název v anglickém jazyce

Cancer-Associated Fibroblasts and Their Role in Cancer Progression

Popis výsledku anglicky

Cancer incidence is increasing worldwide, partially due to the population ageing. This can be linked to advanced and accessible medical care. This trend represents a challenge for healthcare systems in many countries. Development of new diagnostic procedures and therapeutic approaches seems to be necessary for sensible care for therapeutically fragile elderly patients. The cancer microenvironment, especially cancer-associated fibroblasts, represents a promising target for therapeutic manipulation, which has not yet been fully exploited.The chapter summarises data about the origin, markers and biological properties of cancer-associated fibroblasts. The position of cancer-associated fibroblasts in the tumour cellular ecosystem has been established, and their influence on cancer cell proliferation, differentiation, migration and therapeutic resistance is widely recognised.Cancer-associated fibroblasts can potentially result from transition from a broad panel of cell types. The most relevant mechanism seems to be recruitment of normal tissue fibroblasts and mesenchymal stem cells. This is achieved by means of paracrine secretion from cancer cells or via secreted exosomes. CAFs are heterogeneous and represent a potent source of growth factors, pro-inflammatory cytokines, chemokines and also exosomes that significantly activate proliferation and migration of cancer cells.Cancer-associated fibroblasts represent a biologically potent and non-malignant population of cells in malignant tumours. CAF detection and phenotypic and functional characterisation in the distinct types of tumours can refine diagnostics. Moreover, CAFs are an available target for therapeutic interventions, which can potentially advance oncological therapy.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30106 - Anatomy and morphology (plant science to be 1.6)

Projekt

<a href="/cs/project/EF16_019%2F0000785" target="_blank" >EF16_019/0000785: Centrum nádorové ekologie - výzkum nádorového mikroprostředí v organizmu podporujícího růst a šíření nádoru</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Cancer Research: An Interdisciplinary Approach

ISBN

978-3-031-32457-4

Počet stran výsledku

31

Strana od-do

103-133

Počet stran knihy

611

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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