Do Marine Polysaccharides Carrageenans Modulate Non-apoptotic Regulated Cell Deaths ? (a Review)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F23%3A10477067" target="_blank" >RIV/00216208:11110/23:10477067 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Gk~FjptoEp" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=Gk~FjptoEp</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40495-023-00339-7" target="_blank" >10.1007/s40495-023-00339-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Do Marine Polysaccharides Carrageenans Modulate Non-apoptotic Regulated Cell Deaths ? (a Review)

Popis výsledku v původním jazyce

Purpose of Review: A growing number of studies indicate that a network of regulated cell death (RCD) pathways plays a vital role in tumorigenesis suggesting its targeting to be a promising therapeutic avenue for cancer treatment. In this review, we firstly systematically summarize the current knowledge on the impact of carrageenans on different non-conventional non-apoptotic RCDs and explore a therapeutic potential of carrageenans as RCDs-modulating agents. Furthermore, we cover the knowledge gaps and controversies in our understanding of cell death-related carrageenan-mediated effects and highlight the directions of further research aiming at studying the pharmacological potential of carrageenans. Recent Findings: A compelling body of evidence indicates that non-apoptotic RCDs, including necroptosis, ferroptosis, pyroptosis, and autophagy-related cell death, are involved in modulating tumorigenesis and immune response in cancer. Recent advances in our understanding of the role of distinct non-apoptotic RCDs suggest that pharmacological modulation of diverse RCDs is a tempting anti-cancer therapeutic strategy. In particular, carrageenans, which are a group of heterogenous anionic hydrocolloids of polysaccharide nature widely used as food additives (E407 and E407a), have been shown to have anti-viral, anti-cancer, and immunomodulatory activity. The anti-cancer activity of carrageenans is attributed to a certain extent to activation of apoptosis, but the effects of carrageenan on other RCD modes, which can be targeted in oncopathology, are poorly summarized. Summary: Anti-cancer, immunomodulatory, and anti-viral properties of marine polysaccharides carrageenans are at least partly explained by their modulation of RCD modalities, primarily pyroptosis. Thus, carrageenans can be considered promising RCD-regulating agents, which can be therapeutically exploitable. Furthermore, we emphasize the need to consider induction of non-conventional RCDs as one of the possible molecular mechanisms of carrageenan toxicity.

Název v anglickém jazyce

Do Marine Polysaccharides Carrageenans Modulate Non-apoptotic Regulated Cell Deaths ? (a Review)

Popis výsledku anglicky

Purpose of Review: A growing number of studies indicate that a network of regulated cell death (RCD) pathways plays a vital role in tumorigenesis suggesting its targeting to be a promising therapeutic avenue for cancer treatment. In this review, we firstly systematically summarize the current knowledge on the impact of carrageenans on different non-conventional non-apoptotic RCDs and explore a therapeutic potential of carrageenans as RCDs-modulating agents. Furthermore, we cover the knowledge gaps and controversies in our understanding of cell death-related carrageenan-mediated effects and highlight the directions of further research aiming at studying the pharmacological potential of carrageenans. Recent Findings: A compelling body of evidence indicates that non-apoptotic RCDs, including necroptosis, ferroptosis, pyroptosis, and autophagy-related cell death, are involved in modulating tumorigenesis and immune response in cancer. Recent advances in our understanding of the role of distinct non-apoptotic RCDs suggest that pharmacological modulation of diverse RCDs is a tempting anti-cancer therapeutic strategy. In particular, carrageenans, which are a group of heterogenous anionic hydrocolloids of polysaccharide nature widely used as food additives (E407 and E407a), have been shown to have anti-viral, anti-cancer, and immunomodulatory activity. The anti-cancer activity of carrageenans is attributed to a certain extent to activation of apoptosis, but the effects of carrageenan on other RCD modes, which can be targeted in oncopathology, are poorly summarized. Summary: Anti-cancer, immunomodulatory, and anti-viral properties of marine polysaccharides carrageenans are at least partly explained by their modulation of RCD modalities, primarily pyroptosis. Thus, carrageenans can be considered promising RCD-regulating agents, which can be therapeutically exploitable. Furthermore, we emphasize the need to consider induction of non-conventional RCDs as one of the possible molecular mechanisms of carrageenan toxicity.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

10600 - Biological sciences

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Pharmacology Reports

ISSN

2198-641X

e-ISSN

2198-641X

Svazek periodika

9

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

22

Strana od-do

580-601

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85169565860