Brain MRI disease burden and sex differences in cognitive performance of patients with multiple sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10467402" target="_blank" >RIV/00216208:11110/24:10467402 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/24:10467402

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fyTYnL0hGZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=fyTYnL0hGZ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13760-023-02350-7" target="_blank" >10.1007/s13760-023-02350-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Brain MRI disease burden and sex differences in cognitive performance of patients with multiple sclerosis

Popis výsledku v původním jazyce

Background: Although there is evidence that shows worse cognitive functioning in male patients with multiple sclerosis (MS), the role of brain pathology in this context is under-investigated. Objective: To investigate sex differences in cognitive performance of MS patients, in the context of brain pathology and disease burden. Methods: Brain MRI, neurological examination, neuropsychological assessment (Brief International Cognitive Assessment in MS-BICAMS, and Paced Auditory Verbal Learning Test-PASAT), and patient-reported outcome questionnaires were performed/administered in 1052 MS patients. Results: Females had higher raw scores in the Symbol Digit Modalities Test (SDMT) (57.0 vs. 54.0; p &lt; 0.001) and Categorical Verbal Learning Test (CVLT) (63.0 vs. 57.0; p &lt; 0.001), but paradoxically, females evaluated their cognitive performance by MS Neuropsychological Questionnaire as being worse (16.6 vs 14.5, p = 0.004). Females had a trend for a weaker negative correlation between T2 lesion volume and SDMT (ρ = - 0.37 in females vs. - 0.46 in men; interaction p = 0.038). On the other hand, women had a trend for a stronger correlation between Brain Parenchymal Fraction (BPF) and a visual memory test (Spearman&apos;s ρ = 0.31 vs. 0.21; interaction p = 0.016). All these trends were not significant after correction for false discovery rate. Conclusions: Although, females consider their cognition as worse, males had at a group level slightly worse verbal memory and information processing speed. However, the sex differences in cognitive performance were smaller than the variability of scores within the same sex group. Brain MRI measures did not explain the sex differences in cognitive performance among MS patients.

Název v anglickém jazyce

Brain MRI disease burden and sex differences in cognitive performance of patients with multiple sclerosis

Popis výsledku anglicky

Background: Although there is evidence that shows worse cognitive functioning in male patients with multiple sclerosis (MS), the role of brain pathology in this context is under-investigated. Objective: To investigate sex differences in cognitive performance of MS patients, in the context of brain pathology and disease burden. Methods: Brain MRI, neurological examination, neuropsychological assessment (Brief International Cognitive Assessment in MS-BICAMS, and Paced Auditory Verbal Learning Test-PASAT), and patient-reported outcome questionnaires were performed/administered in 1052 MS patients. Results: Females had higher raw scores in the Symbol Digit Modalities Test (SDMT) (57.0 vs. 54.0; p &lt; 0.001) and Categorical Verbal Learning Test (CVLT) (63.0 vs. 57.0; p &lt; 0.001), but paradoxically, females evaluated their cognitive performance by MS Neuropsychological Questionnaire as being worse (16.6 vs 14.5, p = 0.004). Females had a trend for a weaker negative correlation between T2 lesion volume and SDMT (ρ = - 0.37 in females vs. - 0.46 in men; interaction p = 0.038). On the other hand, women had a trend for a stronger correlation between Brain Parenchymal Fraction (BPF) and a visual memory test (Spearman&apos;s ρ = 0.31 vs. 0.21; interaction p = 0.016). All these trends were not significant after correction for false discovery rate. Conclusions: Although, females consider their cognition as worse, males had at a group level slightly worse verbal memory and information processing speed. However, the sex differences in cognitive performance were smaller than the variability of scores within the same sex group. Brain MRI measures did not explain the sex differences in cognitive performance among MS patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Neurologica Belgica

ISSN

0300-9009

e-ISSN

2240-2993

Svazek periodika

124

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

BE - Belgické království

Počet stran výsledku

10

Strana od-do

109-118

Kód UT WoS článku

001044705200001

EID výsledku v databázi Scopus

2-s2.0-85167360190