Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10488501" target="_blank" >RIV/00216208:11110/24:10488501 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/24:10488501

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.n3PoMFGri" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.n3PoMFGri</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13760-024-02676-w" target="_blank" >10.1007/s13760-024-02676-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study

Popis výsledku v původním jazyce

Objectives This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. Materials and methods We included 1.505 patients with 4.966 time points including complete lipid, clinical, and imaging data. The time among lipid, brain MRI and clinical measures was under 90 days. Cross-sectional statistical analysis at baseline was performed using an adjusted linear regression and analysis of longitudinal lipid and MRI measures data was performed using adjusted linear mixed models. Results We found associations between higher high-density lipoprotein cholesterol (HDL-C) and lower brain parenchymal fraction (BPF) at cross-sectional analysis at baseline (B = -0.43, CI 95%: -0.73, -0.12, p = 0.005), as well as in longitudinal analysis over follow-up (B = -0.32 +/- 0.072, chi(2) = 36.6; p = &lt; 0.001). Higher HDL-C was also associated with higher T-2-lesion volume in longitudinal analysis (B = 0.11 +/- 0.023; chi(2) = 23.04; p = &lt; 0.001). We observed a weak negative association between low-density lipoprotein cholesterol (LDL-C) levels and BPF at baseline (B = -0.26, CI 95%: -0.4, -0.11, p = &lt; 0.001) as well as in longitudinal analysis (B = -0.06 +/- 0.03, chi(2) = 4.46; p = 0.03). T2-LV did not show an association with LDL-C. We did not find any association between lipid measures and disability. The effect of lipid levels on MRI measures and disability was minimal (Cohen f2 &lt; 0.02). Conclusions Our results contradict the previously described exclusively positive effect of HDL-C on brain atrophy in patients with MS. Higher LDL-C was weakly associated with higher brain atrophy but not with higher lesion burden.

Název v anglickém jazyce

Lipid and brain volumetric measures in multiple sclerosis patients: findings from a large observational study

Popis výsledku anglicky

Objectives This study aimed to investigate relationships between cholesterol profile, brain volumetric MRI, and clinical measures in a large observational cohort of multiple sclerosis (MS) patients. Materials and methods We included 1.505 patients with 4.966 time points including complete lipid, clinical, and imaging data. The time among lipid, brain MRI and clinical measures was under 90 days. Cross-sectional statistical analysis at baseline was performed using an adjusted linear regression and analysis of longitudinal lipid and MRI measures data was performed using adjusted linear mixed models. Results We found associations between higher high-density lipoprotein cholesterol (HDL-C) and lower brain parenchymal fraction (BPF) at cross-sectional analysis at baseline (B = -0.43, CI 95%: -0.73, -0.12, p = 0.005), as well as in longitudinal analysis over follow-up (B = -0.32 +/- 0.072, chi(2) = 36.6; p = &lt; 0.001). Higher HDL-C was also associated with higher T-2-lesion volume in longitudinal analysis (B = 0.11 +/- 0.023; chi(2) = 23.04; p = &lt; 0.001). We observed a weak negative association between low-density lipoprotein cholesterol (LDL-C) levels and BPF at baseline (B = -0.26, CI 95%: -0.4, -0.11, p = &lt; 0.001) as well as in longitudinal analysis (B = -0.06 +/- 0.03, chi(2) = 4.46; p = 0.03). T2-LV did not show an association with LDL-C. We did not find any association between lipid measures and disability. The effect of lipid levels on MRI measures and disability was minimal (Cohen f2 &lt; 0.02). Conclusions Our results contradict the previously described exclusively positive effect of HDL-C on brain atrophy in patients with MS. Higher LDL-C was weakly associated with higher brain atrophy but not with higher lesion burden.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Neurologica Belgica

ISSN

0300-9009

e-ISSN

2240-2993

Svazek periodika

124

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

BE - Belgické království

Počet stran výsledku

8

Strana od-do

1981-1988

Kód UT WoS článku

001342173300005

EID výsledku v databázi Scopus

2-s2.0-85207325028