Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10497681" target="_blank" >RIV/00216208:11110/25:10497681 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-9vJFcpnfQ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=-9vJFcpnfQ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jnha.2025.100512" target="_blank" >10.1016/j.jnha.2025.100512</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study

Popis výsledku v původním jazyce

Aims: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after &gt;=18 months of intervention. Methods: 298 community-dwelling older adults (&gt;70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). Results: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried&apos;s frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved &gt;=1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. Conclusions: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.

Název v anglickém jazyce

Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study

Popis výsledku anglicky

Aims: Type 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after &gt;=18 months of intervention. Methods: 298 community-dwelling older adults (&gt;70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341). Results: Mean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried&apos;s frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved &gt;=1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants. Conclusions: The MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30227 - Geriatrics and gerontology

Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nutrition, Health and Aging

ISSN

1279-7707

e-ISSN

1760-4788

Svazek periodika

29

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

7

Strana od-do

100512

Kód UT WoS článku

001434618000001

EID výsledku v databázi Scopus

2-s2.0-85217980883