Effect of Methylprednisolone on Ischemic Brain Edema After Temporary Occlusion of the Middle Cerebral Artery in Rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10506732" target="_blank" >RIV/00216208:11110/25:10506732 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WvaIzhcCWv" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=WvaIzhcCWv</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.935600" target="_blank" >10.33549/physiolres.935600</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Methylprednisolone on Ischemic Brain Edema After Temporary Occlusion of the Middle Cerebral Artery in Rats

Popis výsledku v původním jazyce

We studied the effect of Methylpredisolone (MP) on ischemic brain edema after temporary occlusion of the middle cerebral artery for 90 min (MCAo90). We verified the presence of ischemic edema by determining the brain water content (BWC) by measuring dry/wet weight and by examining MRI-T2-weighted imaging, T2 relaxation times and apparent diffusion coefficient (ADC). In another group, animals were administered MP intraperitoneally 30 min after MCAo90, followed by 24 h reperfusion (MCAoMP). Edema changes were documented by the same MRI examinations. A statistically significant increase in BWC was found between the post-MCAo90 group of animals and the intact animals, demonstrating the presence of edema in the former group. A statistically significant increase in ADC was observed in the MCAo group, indicating the presence of vasogenic edema. A statistically significant difference was demonstrated between the MCAo and MCAoMP groups, with no statistically significant difference between the CG and MCAoMP groups, demonstrating a reduction in ischemic brain swelling after MP administration. The main effect of MP on ischemic brain edema is attributed to its antioxidant capacity. It can be assumed that this capacity of MP, with its complex impact on cellular metabolism, affects the movement of water in the brain and reduces ischemic brain edema.

Název v anglickém jazyce

Effect of Methylprednisolone on Ischemic Brain Edema After Temporary Occlusion of the Middle Cerebral Artery in Rats

Popis výsledku anglicky

We studied the effect of Methylpredisolone (MP) on ischemic brain edema after temporary occlusion of the middle cerebral artery for 90 min (MCAo90). We verified the presence of ischemic edema by determining the brain water content (BWC) by measuring dry/wet weight and by examining MRI-T2-weighted imaging, T2 relaxation times and apparent diffusion coefficient (ADC). In another group, animals were administered MP intraperitoneally 30 min after MCAo90, followed by 24 h reperfusion (MCAoMP). Edema changes were documented by the same MRI examinations. A statistically significant increase in BWC was found between the post-MCAo90 group of animals and the intact animals, demonstrating the presence of edema in the former group. A statistically significant increase in ADC was observed in the MCAo group, indicating the presence of vasogenic edema. A statistically significant difference was demonstrated between the MCAo and MCAoMP groups, with no statistically significant difference between the CG and MCAoMP groups, demonstrating a reduction in ischemic brain swelling after MP administration. The main effect of MP on ischemic brain edema is attributed to its antioxidant capacity. It can be assumed that this capacity of MP, with its complex impact on cellular metabolism, affects the movement of water in the brain and reduces ischemic brain edema.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

1802-9973

Svazek periodika

74

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

861-869

Kód UT WoS článku

001631813000014

EID výsledku v databázi Scopus

2-s2.0-105020864360