Narcolepsy and circadian rhythm disorders: diagnosis and management

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F25%3A10506822" target="_blank" >RIV/00216208:11110/25:10506822 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/B978-0-443-30004-2.00014-6" target="_blank" >https://doi.org/10.1016/B978-0-443-30004-2.00014-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-443-30004-2.00014-6" target="_blank" >10.1016/B978-0-443-30004-2.00014-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Narcolepsy and circadian rhythm disorders: diagnosis and management

Popis výsledku v původním jazyce

There is increasing evidence that circadian rhythm abnormalities are involved in the pathophysiology of narcolepsy. The primary circadian pacemaker, the suprachiasmatic nucleus, has a strong influence on hypocretin release. Experimental data have demonstrated the existence of functional hypocretin neurons and a pineal gland circuit able to modulate melatonin production. Clinical data support altered circadian rhythm of melatonin concentration in some hypocretin-deficient patients with a potential connection to daytime sleepiness and abnormal circadian rhythm of body temperature. Clinical manifestations of the disease suggest some circadian aspects as well. Comorbidity of narcolepsy with primary circadian sleep-wake disorders is extremely rare; however, daytime sleepiness may be seen in almost all circadian sleep-wake rhythm disorders with varying severity and timing. Excessive daytime sleepiness and/or difficulties with nocturnal sleep may present differential diagnostic challenges and should be verified by objective examination: most frequently by actigraphy, if necessary, by polysomnography and multiple sleep latency test. Therapeutic approaches include behavioral and pharmaceutical procedures, while melatonin receptor agonists and dual orexin receptor agonists may represent future trends.

Název v anglickém jazyce

Narcolepsy and circadian rhythm disorders: diagnosis and management

Popis výsledku anglicky

There is increasing evidence that circadian rhythm abnormalities are involved in the pathophysiology of narcolepsy. The primary circadian pacemaker, the suprachiasmatic nucleus, has a strong influence on hypocretin release. Experimental data have demonstrated the existence of functional hypocretin neurons and a pineal gland circuit able to modulate melatonin production. Clinical data support altered circadian rhythm of melatonin concentration in some hypocretin-deficient patients with a potential connection to daytime sleepiness and abnormal circadian rhythm of body temperature. Clinical manifestations of the disease suggest some circadian aspects as well. Comorbidity of narcolepsy with primary circadian sleep-wake disorders is extremely rare; however, daytime sleepiness may be seen in almost all circadian sleep-wake rhythm disorders with varying severity and timing. Excessive daytime sleepiness and/or difficulties with nocturnal sleep may present differential diagnostic challenges and should be verified by objective examination: most frequently by actigraphy, if necessary, by polysomnography and multiple sleep latency test. Therapeutic approaches include behavioral and pharmaceutical procedures, while melatonin receptor agonists and dual orexin receptor agonists may represent future trends.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Narcolepsy: Integrating Basic and Clinical Knowledge

ISBN

978-0-443-30004-2

Počet stran výsledku

14

Strana od-do

251-264

Počet stran knihy

646

Název nakladatele

Academic Press

Místo vydání

Amsterdam

Kód UT WoS kapitoly

—