Gestational progesterone suppresses embryotoxic action of the complement system to chick embryo

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A00003806" target="_blank" >RIV/00216208:11120/01:00003806 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Gestational progesterone suppresses embryotoxic action of the complement system to chick embryo

Popis výsledku v původním jazyce

In this paper the relation between progesterone levels and embryotoxic effect of serum complement was studied. The aim of this study was to validate hypothesis that progesterone is strong inhibitor of complement embryotoxic action. We used chick embryo like an experimental model for evidence of our hypothesis. We treated chick embryos by sera acquired from healthy pregnant woman with physiologically elevated levels of progesterone and normal complement activity. We investigated embryotoxicity of these sera. We noticed a significant decrease of sera embryotoxicity inversely related to serum levels of progesterone. The embryotoxicity of sera is reversally dependent on progesterone level. These findings bring a new knowledge to the role of progesterone and complement system mainly in initial stages of pregnancy and in some cases of spontaneous abortions.

Název v anglickém jazyce

Gestational progesterone suppresses embryotoxic action of the complement system to chick embryo

Popis výsledku anglicky

In this paper the relation between progesterone levels and embryotoxic effect of serum complement was studied. The aim of this study was to validate hypothesis that progesterone is strong inhibitor of complement embryotoxic action. We used chick embryo like an experimental model for evidence of our hypothesis. We treated chick embryos by sera acquired from healthy pregnant woman with physiologically elevated levels of progesterone and normal complement activity. We investigated embryotoxicity of these sera. We noticed a significant decrease of sera embryotoxicity inversely related to serum levels of progesterone. The embryotoxicity of sera is reversally dependent on progesterone level. These findings bring a new knowledge to the role of progesterone and complement system mainly in initial stages of pregnancy and in some cases of spontaneous abortions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

5

Strana od-do

33-37

Kód UT WoS článku

000167337500007

EID výsledku v databázi Scopus

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