Experimental pharmacotherapy of opioid sensitization

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A43902434" target="_blank" >RIV/00216208:11120/01:43902434 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Experimental pharmacotherapy of opioid sensitization

Popis výsledku v původním jazyce

This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Sensitisation hasbeen recently one of the main subjects of interest in the research of drug addiction. Contrary to tolerance, sensitisation is characterised by increased behavioural reaction after repeated administration of a drug. Sensitisation seems to be one of the causes of dependence generation on the opioids and relapse in ex-addict people. This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Most studies focus on the dopaminergic, glutamatergic, gabaergic and serotoninergic receptor systems. However, none of the tested substances has proved to be ideal for sensitis

Název v anglickém jazyce

Experimental pharmacotherapy of opioid sensitization

Popis výsledku anglicky

This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Sensitisation hasbeen recently one of the main subjects of interest in the research of drug addiction. Contrary to tolerance, sensitisation is characterised by increased behavioural reaction after repeated administration of a drug. Sensitisation seems to be one of the causes of dependence generation on the opioids and relapse in ex-addict people. This article presents a review of findings made until now within the experimental treatment of sensitisation mainly on locomotion stimulating effects of opioids in mice and rats and potential neurobiological mechanism of its generation. Most studies focus on the dopaminergic, glutamatergic, gabaergic and serotoninergic receptor systems. However, none of the tested substances has proved to be ideal for sensitis

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Homeostasis in Health and Disease

ISSN

0960-7560

e-ISSN

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Svazek periodika

41

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

123-131

Kód UT WoS článku

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EID výsledku v databázi Scopus

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