Hypocaloric diet reduces exercise-induced alpha 2-adrenergic antilipolytic effect and alpha 2-adrenergic receptor mRNA levels in adipose tissue of obese women
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00002995" target="_blank" >RIV/00216208:11120/02:00002995 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1210/jc.87.3.1274" target="_blank" >http://dx.doi.org/10.1210/jc.87.3.1274</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.87.3.1274" target="_blank" >10.1210/jc.87.3.1274</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Hypocaloric diet reduces exercise-induced alpha 2-adrenergic antilipolytic effect and alpha 2-adrenergic receptor mRNA levels in adipose tissue of obese women
Popis výsledku v původním jazyce
Previous investigations have shown that alpha2-adrenoceptor (alpha2-AR) stimulation blunts lipid mobilization during physiological activation of the sympathetic nervous system promoted by exercise in se abdominal adipose tissue (SCAAT) in obese men. To investigate the effect of a low calorie diet (LCD) on the alpha2-adrenergic responsiveness and on the expression of alpha2-AR and beta2-adrenoceptor (beta2-AR) in SCAAT, 11 obese women (weight: 99.1 +/- 4.6 kg; body mass index: 34.3 +/- 1.1 kg/m(2)) received a 12-wk diet providing 500 kcal/d less than their usual diet. The exercise-induced alpha2-adrenergic antilipolytic effect was investigated in SCAAT before and at the end of LCD. Changes in extracellular glycerol concentration and local blood flow were measured in SCAAT during a 45-min exercise bout (50% of heart rate reserve) using a control microdialysis probe and a probe supplemented with the alpha2-AR antagonist phentolamine. SCAAT biopsies were performed for determination of mRNA
Název v anglickém jazyce
Hypocaloric diet reduces exercise-induced alpha 2-adrenergic antilipolytic effect and alpha 2-adrenergic receptor mRNA levels in adipose tissue of obese women
Popis výsledku anglicky
Previous investigations have shown that alpha2-adrenoceptor (alpha2-AR) stimulation blunts lipid mobilization during physiological activation of the sympathetic nervous system promoted by exercise in se abdominal adipose tissue (SCAAT) in obese men. To investigate the effect of a low calorie diet (LCD) on the alpha2-adrenergic responsiveness and on the expression of alpha2-AR and beta2-adrenoceptor (beta2-AR) in SCAAT, 11 obese women (weight: 99.1 +/- 4.6 kg; body mass index: 34.3 +/- 1.1 kg/m(2)) received a 12-wk diet providing 500 kcal/d less than their usual diet. The exercise-induced alpha2-adrenergic antilipolytic effect was investigated in SCAAT before and at the end of LCD. Changes in extracellular glycerol concentration and local blood flow were measured in SCAAT during a 45-min exercise bout (50% of heart rate reserve) using a control microdialysis probe and a probe supplemented with the alpha2-AR antagonist phentolamine. SCAAT biopsies were performed for determination of mRNA
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FB - Endokrinologie, diabetologie, metabolismus, výživa
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA303%2F00%2F0649" target="_blank" >GA303/00/0649: Vliv výživy s vysokým podílem tuků na regulaci metabolismu tukové tkáně</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2002
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Clinical Endocrinology and Metabolism
ISSN
0021-972X
e-ISSN
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Svazek periodika
87
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
1274-1281
Kód UT WoS článku
000174620600053
EID výsledku v databázi Scopus
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