Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003696" target="_blank" >RIV/00216208:11120/02:00003696 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo

Popis výsledku v původním jazyce

Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexedcisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart s

Název v anglickém jazyce

Embryotoxicity of cisplatin nad a cisplatin-procaine complex (DPR) studied in chick embryo

Popis výsledku anglicky

Cisplatin is widely used as an antitumor drug. To reduce its toxic side effects in patients, cisplatin has been bound with procaine in a cisplatin-procaine complex (DPR). The lethal and teratogenic effects of cisplatin alone and of complexcd cisplatin were determined in the chick embryo in ovo in order to compare their influence on rapidly proliferating embryonic tissues. The embryotoxic (lethal + teratogenic) effect was examined after a single intra-amniotic injection of one of six different doses, ranging from 0.03 to30.0 mug, on embryonic days (ED) 3, 4 or 5. The minimal embryotoxic dose was lower for cisplatin alone (0.03-0.3 mug) than for cisplatin in the DPR complex (0.3-3.0 mug), suggesting that cisplatin alone is more embryotoxic than complexedcisplatin. Both substances caused malformations in the surviving embryos evaluated on ED 9. These malformations included microphthalmia, Microcephaly, hypoplasia of the upper and lower jaw, cleft beak, and haemocephaly. Moreover. heart s

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

—

Svazek periodika

49

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

394-400

Kód UT WoS článku

000180614700007

EID výsledku v databázi Scopus

—