Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003698" target="_blank" >RIV/00216208:11120/02:00003698 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/sj.ijo.0802072" target="_blank" >http://dx.doi.org/10.1038/sj.ijo.0802072</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/sj.ijo.0802072" target="_blank" >10.1038/sj.ijo.0802072</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men

Popis výsledku v původním jazyce

The aim of the study was to investigate whether a long-lasting bout of exercise modifies the lipolytic beta- and anti lipolytiC-alpha(2)-adrenergic effect and the antilipolytic effect of insulin in obese subjects. Biopsies of abdominal subcutaneous adipose tissue were performed before and immediately after 2 h exercise (at 50% of VO2max) on an ergometric bicycle. Nine healthy obese male subjects (mean age 38.0 +/- 3.5y; mean body mass index (BMI) 35.6 +/- 3.9kg/m(2)) were included in the experiment. Thelipolytic responsiveness to adrenaline, isoprenaline (beta-adrenergic agonist), UK-14304 (alpha(2)-adrenergic agonist) and insulin was studied in the isolated fat cell obtained by biopsies of subcutaneous adipose tissue from the peri-umbilical region before and after exercise. After exercise, an increase was observed in spontaneous lipolytic rate, and in the lipolytic effect of isoprenaline, but no modification in the lipolytic action of adrenaline. Antilipolytic effects of UK-14304 and

Název v anglickém jazyce

Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men

Popis výsledku anglicky

The aim of the study was to investigate whether a long-lasting bout of exercise modifies the lipolytic beta- and anti lipolytiC-alpha(2)-adrenergic effect and the antilipolytic effect of insulin in obese subjects. Biopsies of abdominal subcutaneous adipose tissue were performed before and immediately after 2 h exercise (at 50% of VO2max) on an ergometric bicycle. Nine healthy obese male subjects (mean age 38.0 +/- 3.5y; mean body mass index (BMI) 35.6 +/- 3.9kg/m(2)) were included in the experiment. Thelipolytic responsiveness to adrenaline, isoprenaline (beta-adrenergic agonist), UK-14304 (alpha(2)-adrenergic agonist) and insulin was studied in the isolated fat cell obtained by biopsies of subcutaneous adipose tissue from the peri-umbilical region before and after exercise. After exercise, an increase was observed in spontaneous lipolytic rate, and in the lipolytic effect of isoprenaline, but no modification in the lipolytic action of adrenaline. Antilipolytic effects of UK-14304 and

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Obesity

ISSN

0307-0565

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1373-1378

Kód UT WoS článku

000178571300013

EID výsledku v databázi Scopus

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