Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00011166" target="_blank" >RIV/00216208:11120/02:00011166 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice

Popis výsledku v původním jazyce

Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid (EA) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is naturally occuring phenolic compound which is found in a variety of soft fruits and vegetables. Effect of this compound on immunosupressive activity of mutagens was followed in vivo by the chemiluminiscence test. In theAmes assay, ellagic acid at concentrations of 300 and 30 g/plate demonstrably inhibits the mutagenic activity of two indirect mutagens: IQ and AFB1. The concentration of 300 g per plate had the strongest effect on mutagenicity of all concentrations of IQ in strain TA 98 of Salmonella typhimurium whereas in strain TA 100, it was 30 g per dish of ellagic acid that was more effective than 300 g/plate. Also in combination with different concentrations of AFB1 ellagic acid was proved to be a

Název v anglickém jazyce

Antimutagenic Effect of Ellagic Acid and its Effect on the Immune Response in Mice

Popis výsledku anglicky

Using the Ames bacterial mutagenicity test and an in vivo micronucleus test, we investigated the antigenotoxic effect of ellagic acid (EA) against the genotoxicity of three mutagens: aminomethylimidazo-quinoline (IQ), aflatoxin B1 (AFB1), and N-nitroso-N-methylurea (MNU). Ellagic acid is naturally occuring phenolic compound which is found in a variety of soft fruits and vegetables. Effect of this compound on immunosupressive activity of mutagens was followed in vivo by the chemiluminiscence test. In theAmes assay, ellagic acid at concentrations of 300 and 30 g/plate demonstrably inhibits the mutagenic activity of two indirect mutagens: IQ and AFB1. The concentration of 300 g per plate had the strongest effect on mutagenicity of all concentrations of IQ in strain TA 98 of Salmonella typhimurium whereas in strain TA 100, it was 30 g per dish of ellagic acid that was more effective than 300 g/plate. Also in combination with different concentrations of AFB1 ellagic acid was proved to be a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NJ6138" target="_blank" >NJ6138: Sledování antimutagenní a imunomodulační aktivity přírodních látek</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Czech Journal of Food Sciences

ISSN

1212-1800

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

181-191

Kód UT WoS článku

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EID výsledku v databázi Scopus

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