Hyperprolaktinémie po nízké dávce amisulpridu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F04%3A00001289" target="_blank" >RIV/00216208:11120/04:00001289 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/04:00000343

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hyperprolactinemia after low dose of Amisulpride

Popis výsledku v původním jazyce

Objectives: Amisulpride in antipsychotic doses can induce hyperprolactinemia. The aim of this study was to prove whether the same is true for low doses of amisulpride. Methodology: Plasma prolactin levels were measured in 5 males and 5 females with depressive symptoms who were treated with 50 mg of amisulpride per day as an augmentation to antidepressants (n=5), benzodiazepine anxiolytics (n=8) or in monotherapy (n=1). Six of these patients were assessed prior to onset of amisulpride treatment and after10 days of amisulpride use. Four patients had been using amisulpride for more than a month. Results: There was a significant increase of prolactin levels from mean 16+-6 ng/ml to 113+-65 ng/ml (median 14.5 ng/ml to median 92 ng/ml; Wilcoxon matched pairtest, p=0.027). All patients had hyperprolactinemia (30-200 ng/ml). The prolactinaemia was significantly higher in females (mean 160+-50 ng/ml; median 198 ng/ml) than in males (mean 48+-12 ng/ml; median 48 ng/ml; Mann-Whitney U test, p=0

Název v anglickém jazyce

Hyperprolactinemia after low dose of Amisulpride

Popis výsledku anglicky

Objectives: Amisulpride in antipsychotic doses can induce hyperprolactinemia. The aim of this study was to prove whether the same is true for low doses of amisulpride. Methodology: Plasma prolactin levels were measured in 5 males and 5 females with depressive symptoms who were treated with 50 mg of amisulpride per day as an augmentation to antidepressants (n=5), benzodiazepine anxiolytics (n=8) or in monotherapy (n=1). Six of these patients were assessed prior to onset of amisulpride treatment and after10 days of amisulpride use. Four patients had been using amisulpride for more than a month. Results: There was a significant increase of prolactin levels from mean 16+-6 ng/ml to 113+-65 ng/ml (median 14.5 ng/ml to median 92 ng/ml; Wilcoxon matched pairtest, p=0.027). All patients had hyperprolactinemia (30-200 ng/ml). The prolactinaemia was significantly higher in females (mean 160+-50 ng/ml; median 198 ng/ml) than in males (mean 48+-12 ng/ml; median 48 ng/ml; Mann-Whitney U test, p=0

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00B122" target="_blank" >LN00B122: Centrum neuropsychiatrických studií</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

4

Strana od-do

419-422

Kód UT WoS článku

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EID výsledku v databázi Scopus

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