Glutamátergní hypotéza schizofrenie: úloha Na+/K+- závisejícího transportu glutamátu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F05%3A00009644" target="_blank" >RIV/00216208:11120/05:00009644 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/05:00000488

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Glutamatergic hypothesis of schizophrenia: involvement of Na+/K+-dependent glutamate transport

Popis výsledku v původním jazyce

Hypothetical model based on deficient glutamatergic neurotransmission caused by hyperactive glutamate transport in astrocytes surrounding excitatory synapses in the prefrontal cortex is examined in relation to the etiology of schizophrenia. The model isconsistent with actions of neuroleptics, such as clozapine, in animal experiments and it is strongly supported by recent findings of increased expression of glutamate transporter GLT in prefrontal cortex of patients with schizophrenia. It is proposed that mechanisms regulating glutamate transport be investigated as potential targets for novel classes of neuroactive compounds with neuroleptic characteristics. Development of new efficient technique designed specifically for the purpose of studying rapid activity-dependent translocation of glutamate transportes and associated molecules such as Na+; K+-ATPase is essential and should be encouraged.

Název v anglickém jazyce

Glutamatergic hypothesis of schizophrenia: involvement of Na+/K+-dependent glutamate transport

Popis výsledku anglicky

Hypothetical model based on deficient glutamatergic neurotransmission caused by hyperactive glutamate transport in astrocytes surrounding excitatory synapses in the prefrontal cortex is examined in relation to the etiology of schizophrenia. The model isconsistent with actions of neuroleptics, such as clozapine, in animal experiments and it is strongly supported by recent findings of increased expression of glutamate transporter GLT in prefrontal cortex of patients with schizophrenia. It is proposed that mechanisms regulating glutamate transport be investigated as potential targets for novel classes of neuroactive compounds with neuroleptic characteristics. Development of new efficient technique designed specifically for the purpose of studying rapid activity-dependent translocation of glutamate transportes and associated molecules such as Na+; K+-ATPase is essential and should be encouraged.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NF7626" target="_blank" >NF7626: Hladiny mozkového glutamátu a podjednotková stavba glutamátového receptoru NMDA typu u schizofrenie: experimentálně - klinická studie.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biomedical Science

ISSN

1021-7770

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

TW - Čínská republika (Tchaj-wan)

Počet stran výsledku

10

Strana od-do

975-984

Kód UT WoS článku

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EID výsledku v databázi Scopus

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