Regionální metabolismus mozku jako prediktor výkonu na test cesty u schizofrenie. 18FDG PET kovariační studie

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F06%3A00000024" target="_blank" >RIV/00216208:11120/06:00000024 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/06:00000538

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study

Popis výsledku v původním jazyce

Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysiswe compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better perform

Název v anglickém jazyce

Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A 18FDG PET covariation study

Popis výsledku anglicky

Objectives: With the aim to indicate the functional anatomical substrate of cognitive dysfunction in schizophrenia we evaluated the relationship between resting brain metabolism and performance on the Trail Making Test (TMT). As the prerequisite analysiswe compared the performance in Part A and B of the TMT between schizophrenic patients and controls. Resting brain metabolism was investigated by 18FDG positron emission tomography (PET) as the probe for the relative regional synaptic strength and density. Methods: 18FDG PET data were analyzed by SPM99 with TMT A and B as the covariate (pL0.001). Results: Schizophrenic patients (N=42) had worse performance in both TMT A and B compared to controls (N=42). In schizophrenic subjects 18FDG PET did not predict the performance on Part A (psychomotor speed) but predicted that for Part B (set-shifting and flexibility) of the TMT. The 18FDG uptake in the superior, middle and inferior frontal gyruses bilaterally was associated with better perform

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

27

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

13

Strana od-do

587-594

Kód UT WoS článku

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EID výsledku v databázi Scopus

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