Endogenní IL-1beta indukuje v hypotalamu vlastní expresi, nepůsobí na expresi IL-6 a aktivuje HPA osu a uvolňování prolaktinu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F06%3A00000920" target="_blank" >RIV/00216208:11120/06:00000920 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Exogenous IL-1? induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA Axis and prolactin release

Popis výsledku v původním jazyce

Objective: Proinflammatory cytokines IL-1ß, and IL-6 are synthesized in the brain, where they exert local regulatory functions. Our aim was to find out whether, along with the activation of hypothalamo-pituitary-adrenocortical (HPA) axis and prolactin (PRL), the acute systemic enhancement of IL-1ß affects its own production in the hypothalamus as well as that of IL-6. Method: Forty five minutes after a single i.p. administration of recombinant rat IL-1ß (5 ?g/ kg) to male Long Evans rats we estimated the expression of IL-1ß and IL-6 mRNA in the hypothalamus by real time PCR, ACTH, corticosterone (CORT), and PRL by RIA Results: IL-1ß administration stimulated the expression of IL-1ß mRNA in the hypothalamus by 99 %, but not that of IL-6. It also significantly activated plasma levels of ACTH, PRL, CORT, and CORT production in adrenal gland. Conclusion: These results indicate that acute peripheral enhancement of IL-1ß may induce neuroendocrine changes also via the immediate activation of

Název v anglickém jazyce

Exogenous IL-1? induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA Axis and prolactin release

Popis výsledku anglicky

Objective: Proinflammatory cytokines IL-1ß, and IL-6 are synthesized in the brain, where they exert local regulatory functions. Our aim was to find out whether, along with the activation of hypothalamo-pituitary-adrenocortical (HPA) axis and prolactin (PRL), the acute systemic enhancement of IL-1ß affects its own production in the hypothalamus as well as that of IL-6. Method: Forty five minutes after a single i.p. administration of recombinant rat IL-1ß (5 ?g/ kg) to male Long Evans rats we estimated the expression of IL-1ß and IL-6 mRNA in the hypothalamus by real time PCR, ACTH, corticosterone (CORT), and PRL by RIA Results: IL-1ß administration stimulated the expression of IL-1ß mRNA in the hypothalamus by 99 %, but not that of IL-6. It also significantly activated plasma levels of ACTH, PRL, CORT, and CORT production in adrenal gland. Conclusion: These results indicate that acute peripheral enhancement of IL-1ß may induce neuroendocrine changes also via the immediate activation of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endocrine Regulations

ISSN

1210-0668

e-ISSN

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Svazek periodika

40

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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