Polymorfismus genů HLA, NFKB1 a NFKBIA u pacientů s autoimunitním diabetes mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F07%3A00000248" target="_blank" >RIV/00216208:11120/07:00000248 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients

Popis výsledku v původním jazyce

Type 1 diabetes mellitus (T1DM) is one of the long-time studied autoimmune disorders. The triggering of the autoimmune process has been ascribed to various genes active in the regulation of the cytokine gene transcription including the Rel/NF-&#954;B gene family. In our study the gene polymorphism of HLA class II, NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) and NFKBIA (inhibitor of nuclear factor kappa B) was tested. Patients were divided into the subgroups in relation to the disease type: T1DM in children, T1DM in adults, and Latent Autoimmune Diabetes in Adults (LADA). HLA-DRB1*04 and HLA-DQB1*0302 have been detected as risk factors for T1DM in adults and particularly in children (P< 0.0001, OR=22.9 and 46.5 respectively). HLA-DRB1*03 has been found as a single risk factor for LADA (P< 0.0001, OR=4.9). We detected 15 alleles for the NFKB1 gene polymorphism (CA-repeats) in the Czech population. The alleles were ranging in size from 114 -142 bp correspo

Název v anglickém jazyce

HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients

Popis výsledku anglicky

Type 1 diabetes mellitus (T1DM) is one of the long-time studied autoimmune disorders. The triggering of the autoimmune process has been ascribed to various genes active in the regulation of the cytokine gene transcription including the Rel/NF-&#954;B gene family. In our study the gene polymorphism of HLA class II, NFKB1 (nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) and NFKBIA (inhibitor of nuclear factor kappa B) was tested. Patients were divided into the subgroups in relation to the disease type: T1DM in children, T1DM in adults, and Latent Autoimmune Diabetes in Adults (LADA). HLA-DRB1*04 and HLA-DQB1*0302 have been detected as risk factors for T1DM in adults and particularly in children (P< 0.0001, OR=22.9 and 46.5 respectively). HLA-DRB1*03 has been found as a single risk factor for LADA (P< 0.0001, OR=4.9). We detected 15 alleles for the NFKB1 gene polymorphism (CA-repeats) in the Czech population. The alleles were ranging in size from 114 -142 bp correspo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Experimental and Clinical Endocrinology & Diabetes

ISSN

0947-7349

e-ISSN

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Svazek periodika

115

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

124-129

Kód UT WoS článku

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EID výsledku v databázi Scopus

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