Ovlivní "cross-fostering" negativní vliv metamfetaminu na postnatální vývoj potkaních mláďat?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000846" target="_blank" >RIV/00216208:11120/08:00000846 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Does cross-fostering modify the impairing effect of methamphetamine on postnatal development of rat pups?

Popis výsledku v původním jazyce

Our previous studies demonstrated that methamphetamine (MA) administered during gestation and lactation periods impairs maternal behavior as well as the postnatal development of rat pups. The present study tested the hypothesis that the cross-fostering influences the development of rat pups. Mothers were daily exposed to injection of MA (5 mg/kg) and saline for 9 weeks: three weeks prior to impregnation, throughout the entire gestation period and during lactation. As a control (C) females with no injections were used. On postnatal day (PD 1), pups were cross-fostered so that each mother received some of her own and some of the pups of mother with the other treatments. Pup's development and sensorimotor coordination was examined between PD 1 and PD 23.Following tests were used: tail pull (PD 10), righting reflex on surface (PD 12), righting reflex on mid-air (PD 17) and rotarod (PD 23). Our results showed that the birth weight in prenatally MA-exposed pups was lower than controls or sa

Název v anglickém jazyce

Does cross-fostering modify the impairing effect of methamphetamine on postnatal development of rat pups?

Popis výsledku anglicky

Our previous studies demonstrated that methamphetamine (MA) administered during gestation and lactation periods impairs maternal behavior as well as the postnatal development of rat pups. The present study tested the hypothesis that the cross-fostering influences the development of rat pups. Mothers were daily exposed to injection of MA (5 mg/kg) and saline for 9 weeks: three weeks prior to impregnation, throughout the entire gestation period and during lactation. As a control (C) females with no injections were used. On postnatal day (PD 1), pups were cross-fostered so that each mother received some of her own and some of the pups of mother with the other treatments. Pup's development and sensorimotor coordination was examined between PD 1 and PD 23.Following tests were used: tail pull (PD 10), righting reflex on surface (PD 12), righting reflex on mid-air (PD 17) and rotarod (PD 23). Our results showed that the birth weight in prenatally MA-exposed pups was lower than controls or sa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/1A8610" target="_blank" >1A8610: Faktory ovlivňující zdraví potomstva drogově závislých matek</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Svazek periodika

109

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

12

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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