Odlišné vlivy prostředí na etiologii atopických chorob v evropských populacích jako základ studia interakce genů a okolního prostředí

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000994" target="_blank" >RIV/00216208:11120/08:00000994 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions

Popis výsledku v původním jazyce

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens.. The development of these diseases is influenced by both genetic and environmental factors. As the first step in study of such gene-environmentinteractions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukradne. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens from Ukradne were dust mites allergens and cat. In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity.

Název v anglickém jazyce

Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions

Popis výsledku anglicky

Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens.. The development of these diseases is influenced by both genetic and environmental factors. As the first step in study of such gene-environmentinteractions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukradne. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens from Ukradne were dust mites allergens and cat. In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Genetic Predisposition to Disease

ISBN

978-1-60456-835-6

Počet stran výsledku

14

Strana od-do

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Počet stran knihy

278

Název nakladatele

Nova Science Publishers

Místo vydání

New York

Kód UT WoS kapitoly

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