Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00002197" target="_blank" >RIV/00216208:11120/08:00002197 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial

Popis výsledku v původním jazyce

Despite the considerable limitations of an open, non-masked trial, particularly in Menire's disease (MD), a higher dosage of betahistine-dihydrochloride and a long-term treatment seems to be more effective than a low dosage and short-term treatment. Objective. To evaluate the prophylactic effects of a low versus high dosage long-term treatment with betahistine-dihydrochloride on the number of attacks in MD. Patients and methods. We performed an open, non-masked trial, in which patients with MD receivedeither a low dosage of betahistine-dihydrochloride (16 or 24 mg tid) or a higher dosage of 48 mg tid for at least 12 months. The outcome measure was the number of attacks per month during a 3-month period. Non-parametric tests and a random effects modelwere used for statistical analysis. Results. A total of 112 patients were included in the analysis: 50 received betahistine-dihydrochloride in a low dosage (16 mg tid, n=21, 24 mg, n=29) and 62 received 48 mg tid. Follow-up examination ev

Název v anglickém jazyce

Long-term prophylactic treatment of attacks of vertigo in Menire's disease - comparison of a high with a low dosage of betahistine in an open trial

Popis výsledku anglicky

Despite the considerable limitations of an open, non-masked trial, particularly in Menire's disease (MD), a higher dosage of betahistine-dihydrochloride and a long-term treatment seems to be more effective than a low dosage and short-term treatment. Objective. To evaluate the prophylactic effects of a low versus high dosage long-term treatment with betahistine-dihydrochloride on the number of attacks in MD. Patients and methods. We performed an open, non-masked trial, in which patients with MD receivedeither a low dosage of betahistine-dihydrochloride (16 or 24 mg tid) or a higher dosage of 48 mg tid for at least 12 months. The outcome measure was the number of attacks per month during a 3-month period. Non-parametric tests and a random effects modelwere used for statistical analysis. Results. A total of 112 patients were included in the analysis: 50 received betahistine-dihydrochloride in a low dosage (16 mg tid, n=21, 24 mg, n=29) and 62 received 48 mg tid. Follow-up examination ev

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Oto-Laryngologica

ISSN

0001-6489

e-ISSN

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Svazek periodika

128

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NO - Norské království

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000255042200005

EID výsledku v databázi Scopus

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