Activation of hypothalamic NPY, AgRP, MC4R, and IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00001689" target="_blank" >RIV/00216208:11120/09:00001689 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Activation of hypothalamic NPY, AgRP, MC4R, and IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity

Popis výsledku v původním jazyce

Obesity represents a low-grade inflammatory disease and is a risk factor for insulin resistance. Little is known whether this state may contribute to the development of autoimmune inflammatory diseases. The aim of this work was to study the early-life diet-induced obesity in Lewis rats which are known by high susceptibility to autoimmunity. METHODS: Obesity was induced by small litter size (4 pups per litter) followed by high-fat diet (SHF rats). Control rats (8 pups per litter) were fed with standard diet (CN rats). RESULTS: During the study SHF rats had the same body weight gain and caloric intake as CN rats. At the age of 8 weeks SHF showed increased epididymal fat mass and adipocyte volume, impaired glucose tolerance, normal basal fasting insulin,visfatin, and ghrelin levels, lowered adiponectin, and high leptin levels. In the hypothalamic arcuate nucleus, SHF showed increased expressions of the orexigenic neuropeptide-Y (NPY), agouti-related protein (AgRP), and the anorexigenic p

Název v anglickém jazyce

Activation of hypothalamic NPY, AgRP, MC4R, and IL-6 mRNA levels in young Lewis rats with early-life diet-induced obesity

Popis výsledku anglicky

Obesity represents a low-grade inflammatory disease and is a risk factor for insulin resistance. Little is known whether this state may contribute to the development of autoimmune inflammatory diseases. The aim of this work was to study the early-life diet-induced obesity in Lewis rats which are known by high susceptibility to autoimmunity. METHODS: Obesity was induced by small litter size (4 pups per litter) followed by high-fat diet (SHF rats). Control rats (8 pups per litter) were fed with standard diet (CN rats). RESULTS: During the study SHF rats had the same body weight gain and caloric intake as CN rats. At the age of 8 weeks SHF showed increased epididymal fat mass and adipocyte volume, impaired glucose tolerance, normal basal fasting insulin,visfatin, and ghrelin levels, lowered adiponectin, and high leptin levels. In the hypothalamic arcuate nucleus, SHF showed increased expressions of the orexigenic neuropeptide-Y (NPY), agouti-related protein (AgRP), and the anorexigenic p

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/GA305%2F06%2F0427" target="_blank" >GA305/06/0427: Nutriční modulace adjuvantní artritidy: spolupůsobení leptinu a ghrelinu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endocrine Regulations

ISSN

1210-0668

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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