Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00001948" target="_blank" >RIV/00216208:11120/09:00001948 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity

Popis výsledku v původním jazyce

There is a growing evidence that both overnutrition and undernutrition negatively interfere with immune system. The overnutrition has been found to increase susceptibility to the development of inflammatory or autoimmune diseases. On the other hand, starvation or malnutrition has been more associated with increased susceptibility to infections. In the regulation of immune and inflammatory processes, white adipose tissue plays acritical role as an endocrine organ which produces number of active peptides,called adipokines. The adipokines, leptin and adiponectin represent acritical link among nutritional status, metabolism and immunity. Leptin is primarily known as asatiety factor regulating body weight by suppression of appetite and stimulation of energy expenditure, and its serum levels and gene expression in adipocytes strongly correlate with proportion of body fat stores. On the other hand, leptin is apro-inflammatory adipokine inducing Thelper 1cells and may contribute to the develo

Název v anglickém jazyce

Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity

Popis výsledku anglicky

There is a growing evidence that both overnutrition and undernutrition negatively interfere with immune system. The overnutrition has been found to increase susceptibility to the development of inflammatory or autoimmune diseases. On the other hand, starvation or malnutrition has been more associated with increased susceptibility to infections. In the regulation of immune and inflammatory processes, white adipose tissue plays acritical role as an endocrine organ which produces number of active peptides,called adipokines. The adipokines, leptin and adiponectin represent acritical link among nutritional status, metabolism and immunity. Leptin is primarily known as asatiety factor regulating body weight by suppression of appetite and stimulation of energy expenditure, and its serum levels and gene expression in adipocytes strongly correlate with proportion of body fat stores. On the other hand, leptin is apro-inflammatory adipokine inducing Thelper 1cells and may contribute to the develo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endocrine Regulations

ISSN

1210-0668

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

12

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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