The role of prolactin in immune response to bacterial infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00002109" target="_blank" >RIV/00216208:11120/09:00002109 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The role of prolactin in immune response to bacterial infection

Popis výsledku v původním jazyce

Interactions between the neuroendocrine and immune system play an important role in maintaining and restoring homeostasis. Any dysfunction may result in susceptible individuals in septicemia and bacterial infection. We studied toll-like receptors (TLR) and prolactin (PRL) role in defensive reaction of immune system to bacterial infection and hypothesized that PRL takes part in this defensive reaction and has contraregulative role against activation of adrenocortical system. Measuring the expression of PRL, TLR 2 and 4 mRNA levels in CD14+ cells derived from peripheral blood of 20 septic patients at the time of admission (sample A) and then at the moment when symptoms of sepsis disappeared (sample B) revealed no change between the two samples. Similarly, we were not able to detect any statistically significant difference in PRL, TLR2 and 4 protein levels measured by FCM. Preliminary results do not confirm that septic statuses change peripheral PRL, TLR2 and TLR4 expression in CD14+ cell

Název v anglickém jazyce

The role of prolactin in immune response to bacterial infection

Popis výsledku anglicky

Interactions between the neuroendocrine and immune system play an important role in maintaining and restoring homeostasis. Any dysfunction may result in susceptible individuals in septicemia and bacterial infection. We studied toll-like receptors (TLR) and prolactin (PRL) role in defensive reaction of immune system to bacterial infection and hypothesized that PRL takes part in this defensive reaction and has contraregulative role against activation of adrenocortical system. Measuring the expression of PRL, TLR 2 and 4 mRNA levels in CD14+ cells derived from peripheral blood of 20 septic patients at the time of admission (sample A) and then at the moment when symptoms of sepsis disappeared (sample B) revealed no change between the two samples. Similarly, we were not able to detect any statistically significant difference in PRL, TLR2 and 4 protein levels measured by FCM. Preliminary results do not confirm that septic statuses change peripheral PRL, TLR2 and TLR4 expression in CD14+ cell

Druh

D - Stať ve sborníku

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS9970" target="_blank" >NS9970: Úloha prolaktinu v imunitní reakci při bakteriální infekci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceeding of the 2nd European Congress of Immunology

ISBN

978-88-7587-523-7

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

27-30

Název nakladatele

Medimond

Místo vydání

Bologna

Místo konání akce

Berlin

Datum konání akce

13. 9. 2009

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000292190700006