Amygdala and Hippocampal Volumes in Relatives of Patients With Bipolar Disorder: A High-Risk Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00002269" target="_blank" >RIV/00216208:11120/09:00002269 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/09:43914555

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Amygdala and Hippocampal Volumes in Relatives of Patients With Bipolar Disorder: A High-Risk Study

Popis výsledku v původním jazyce

Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have yet been identified. To test whether amygdala or hippocampal volumes represent an endophenotype for BD, we measured mesiotemporal volumes in young affected and unaffected relatives of patients with BD (high-risk design). Method: High-risk participants (aged 15 to 30 years) were recruited from families multiply affected with BID. They included 20 affected and 26 unaffected offspring of parents with primary mood disorders, matched by age and sex with 31 control subjects without a personal or family history of psychiatric disorders. Amygdala and hippocampal volumes were measured on 1.5 Tesla 3-dimensional anatomical magnetic resonance images using standard methods. Results: We found comparable amygdala and hippocampal volumes among unaffected relatives, affected high-risk patients, and control subjects. The exclusion of 6 medicated patients did not change the results. There were

Název v anglickém jazyce

Amygdala and Hippocampal Volumes in Relatives of Patients With Bipolar Disorder: A High-Risk Study

Popis výsledku anglicky

Bipolar disorders (BD) have a strong genetic underpinning, yet no biological vulnerability markers for BD have yet been identified. To test whether amygdala or hippocampal volumes represent an endophenotype for BD, we measured mesiotemporal volumes in young affected and unaffected relatives of patients with BD (high-risk design). Method: High-risk participants (aged 15 to 30 years) were recruited from families multiply affected with BID. They included 20 affected and 26 unaffected offspring of parents with primary mood disorders, matched by age and sex with 31 control subjects without a personal or family history of psychiatric disorders. Amygdala and hippocampal volumes were measured on 1.5 Tesla 3-dimensional anatomical magnetic resonance images using standard methods. Results: We found comparable amygdala and hippocampal volumes among unaffected relatives, affected high-risk patients, and control subjects. The exclusion of 6 medicated patients did not change the results. There were

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Canadian Journal of Psychiatry-Revue Cannadiene de Psychiatrie

ISSN

0706-7437

e-ISSN

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Svazek periodika

54

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000272058900005

EID výsledku v databázi Scopus

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