Granzyme B-induced apoptosis in cancer cells and its regulation (Review)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002812" target="_blank" >RIV/00216208:11120/10:00002812 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/10:8751

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Granzyme B-induced apoptosis in cancer cells and its regulation (Review)

Popis výsledku v původním jazyce

The granzyme B-induced cell death has been traditionally viewed as a primary mechanism that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate harmful target cells including allogeneic, virally infected and tumour cellsGranzyme B (GrB) is the most abundant senne protease which is stored in secretory granules of CTLs and NK cells After recognition of the target cell, the engaged CTLs and NK cells vectonally secrete GrB along with other granule proteins including performinto the immunological synapse From this submicroscopic intercellular cleft GrB translocates into the cytoplasm of the target cell Although several models have been proposed to explain the GrB delivery mechanism, conclusive understanding of this processremains still elusive Once in the cytoplasm, GrB cleaves and activates or inactivates, multiple protein substrates, resulting eventually into apoptotic demise of the target cell This review is focused on the gene structure and expression

Název v anglickém jazyce

Granzyme B-induced apoptosis in cancer cells and its regulation (Review)

Popis výsledku anglicky

The granzyme B-induced cell death has been traditionally viewed as a primary mechanism that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate harmful target cells including allogeneic, virally infected and tumour cellsGranzyme B (GrB) is the most abundant senne protease which is stored in secretory granules of CTLs and NK cells After recognition of the target cell, the engaged CTLs and NK cells vectonally secrete GrB along with other granule proteins including performinto the immunological synapse From this submicroscopic intercellular cleft GrB translocates into the cytoplasm of the target cell Although several models have been proposed to explain the GrB delivery mechanism, conclusive understanding of this processremains still elusive Once in the cytoplasm, GrB cleaves and activates or inactivates, multiple protein substrates, resulting eventually into apoptotic demise of the target cell This review is focused on the gene structure and expression

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Oncology

ISSN

1019-6439

e-ISSN

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Svazek periodika

37

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

18

Strana od-do

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Kód UT WoS článku

000284922700001

EID výsledku v databázi Scopus

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