Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003172" target="_blank" >RIV/00216208:11120/11:00003172 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bbr.2011.05.021" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2011.05.021</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbr.2011.05.021" target="_blank" >10.1016/j.bbr.2011.05.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?

Popis výsledku v původním jazyce

Methamphetamine (MA) is one of the most frequently used illicit drugs worldwide and also one of the most common drugs abused by pregnant women. Repeated administration of psychostimulants induces behavioral sensitization in response to treatment of the same or related drugs in rodents. The effect of prenatal MA exposure on sensitivity to drugs in adulthood is not yet fully determined. Because our most recent studies demonstrated that prenatal MA (5 mg/kg) exposure makes adult rats more sensitive to acute injection of the same drug, we were interested whether the increased sensitivity corresponds with the increased drug-seeking behavior. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult malerats tested in the conditioned place preference (CPP). The following psychostimulant drugs were used as a challenge in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg) and cocaine (10 mg/kg). All psychostimulant drugs induced increased dru

Název v anglickém jazyce

Does prenatal methamphetamine exposure affect the drug-seeking behavior of adult male rats?

Popis výsledku anglicky

Methamphetamine (MA) is one of the most frequently used illicit drugs worldwide and also one of the most common drugs abused by pregnant women. Repeated administration of psychostimulants induces behavioral sensitization in response to treatment of the same or related drugs in rodents. The effect of prenatal MA exposure on sensitivity to drugs in adulthood is not yet fully determined. Because our most recent studies demonstrated that prenatal MA (5 mg/kg) exposure makes adult rats more sensitive to acute injection of the same drug, we were interested whether the increased sensitivity corresponds with the increased drug-seeking behavior. The aim of the present study was to examine the effect of prenatal MA exposure on drug-seeking behavior of adult malerats tested in the conditioned place preference (CPP). The following psychostimulant drugs were used as a challenge in adulthood: MA (5 mg/kg), amphetamine (5 mg/kg) and cocaine (10 mg/kg). All psychostimulant drugs induced increased dru

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioural Brain Research

ISSN

0166-4328

e-ISSN

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Svazek periodika

224

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

80-86

Kód UT WoS článku

000293312200011

EID výsledku v databázi Scopus

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