Lipolytic effects of B-type natriuretic peptide (1-32) in adipose tissue of heart failure patients compared with healthy controls

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003376" target="_blank" >RIV/00216208:11120/11:00003376 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/11:00002471

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jacc.2011.05.042" target="_blank" >http://dx.doi.org/10.1016/j.jacc.2011.05.042</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jacc.2011.05.042" target="_blank" >10.1016/j.jacc.2011.05.042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lipolytic effects of B-type natriuretic peptide (1-32) in adipose tissue of heart failure patients compared with healthy controls

Popis výsledku v původním jazyce

Our goal was to examine the role of B-type natriuretic peptide (BNP) in lipolysis regulation in heart failure (HF) patients. Enhanced adipose tissue lipolysis can contribute to myocardial lipid overload, insulin resistance, and cachexia in advanced HF. Natriuretic peptides were recently recognized to stimulate lipolysis in healthy subjects. 10 nondiabetic HF patients (New York Heart Association functional class III, 50% nonischemic etiology) and 13 healthy subjects (control subjects) of similar age, sex, and body composition underwent a microdialysis study of subcutaneous abdominal adipose tissue. Four microdialysis probes were simultaneously perfused with 0.1 mu M BNP(1-32), 10 mu M BNP(1-32), 10 mu M norepinephrine (NE) or Ringer's solution. Outgoingdialysate glycerol concentration (DGC) was measured as an index of lipolysis. BNP(1-32) exerts strong lipolytic effects in humans. Despite marked elevation of plasma immunoreactive BNP, the responsiveness of adipose tissue to BNP(1-32) i

Název v anglickém jazyce

Lipolytic effects of B-type natriuretic peptide (1-32) in adipose tissue of heart failure patients compared with healthy controls

Popis výsledku anglicky

Our goal was to examine the role of B-type natriuretic peptide (BNP) in lipolysis regulation in heart failure (HF) patients. Enhanced adipose tissue lipolysis can contribute to myocardial lipid overload, insulin resistance, and cachexia in advanced HF. Natriuretic peptides were recently recognized to stimulate lipolysis in healthy subjects. 10 nondiabetic HF patients (New York Heart Association functional class III, 50% nonischemic etiology) and 13 healthy subjects (control subjects) of similar age, sex, and body composition underwent a microdialysis study of subcutaneous abdominal adipose tissue. Four microdialysis probes were simultaneously perfused with 0.1 mu M BNP(1-32), 10 mu M BNP(1-32), 10 mu M norepinephrine (NE) or Ringer's solution. Outgoingdialysate glycerol concentration (DGC) was measured as an index of lipolysis. BNP(1-32) exerts strong lipolytic effects in humans. Despite marked elevation of plasma immunoreactive BNP, the responsiveness of adipose tissue to BNP(1-32) i

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American College of Cardiology

ISSN

0735-1097

e-ISSN

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Svazek periodika

58

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

1119-1125

Kód UT WoS článku

000294449200006

EID výsledku v databázi Scopus

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