The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003404" target="_blank" >RIV/00216208:11120/11:00003404 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s00296-009-1258-z" target="_blank" >http://dx.doi.org/10.1007/s00296-009-1258-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00296-009-1258-z" target="_blank" >10.1007/s00296-009-1258-z</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis
Popis výsledku v původním jazyce
The purpose of this study was to evaluate the effect of beta-(1,3/1,6)-d-glucan isolated from Pleurotus ostreatus (beta-glucan-PO) on prophylactic treatment of adjuvant arthritis (AA) with methotrexate (MTX) in rats. Groups of rats with AA were treated with methotrexate (1 mg/kg/week), beta-glucan-PO (1 mg/kg every second day) or their combination for the period of 28 days from adjuvant application. Body mass, hind paw swelling, arthrogram scores and a level of serum albumin were measured as markers ofinflammation and arthritis. Treatment with low dose of MTX significantly inhibited the markers of both inflammation and arthritis. MTX and its combination with beta-glucan-PO significantly increased body mass of arthritic rats. beta-glucan-PO administered alone significantly decreased both the hind paw swelling and arthritic score. In combination with MTX, beta-glucan-PO markedly potentiated the beneficial effects of MTX, which resulted in a more significant reduction of hind paw swellin
Název v anglickém jazyce
The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis
Popis výsledku anglicky
The purpose of this study was to evaluate the effect of beta-(1,3/1,6)-d-glucan isolated from Pleurotus ostreatus (beta-glucan-PO) on prophylactic treatment of adjuvant arthritis (AA) with methotrexate (MTX) in rats. Groups of rats with AA were treated with methotrexate (1 mg/kg/week), beta-glucan-PO (1 mg/kg every second day) or their combination for the period of 28 days from adjuvant application. Body mass, hind paw swelling, arthrogram scores and a level of serum albumin were measured as markers ofinflammation and arthritis. Treatment with low dose of MTX significantly inhibited the markers of both inflammation and arthritis. MTX and its combination with beta-glucan-PO significantly increased body mass of arthritic rats. beta-glucan-PO administered alone significantly decreased both the hind paw swelling and arthritic score. In combination with MTX, beta-glucan-PO markedly potentiated the beneficial effects of MTX, which resulted in a more significant reduction of hind paw swellin
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
—
Návaznosti
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Rheumatology International
ISSN
0172-8172
e-ISSN
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Svazek periodika
31
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
5
Strana od-do
507-511
Kód UT WoS článku
000288508500011
EID výsledku v databázi Scopus
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