Iron overload and HFE gene mutations in Czech patients with chronic liver diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A00003586" target="_blank" >RIV/00216208:11120/12:00003586 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/12:#0000057

Výsledek na webu

<a href="http://dx.doi.org/10.3233/DMA-2012-0861" target="_blank" >http://dx.doi.org/10.3233/DMA-2012-0861</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2012/790464" target="_blank" >10.1155/2012/790464</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Iron overload and HFE gene mutations in Czech patients with chronic liver diseases

Popis výsledku v původním jazyce

The aim of the study was to identify the prevalence of HFE gene mutations in Czech patients with chronic liver diseases and the influence of the mutations on iron status. The presence of HFE gene mutations (C282Y, H63D, and S65C) analyzed by the PCR-RFLPmethod, presence of cirrhosis, and serum iron indices were compared among 454 patients with different chronic liver diseases (51 with chronic hepatitis B, 122 with chronic hepatitis C, 218 with alcoholic liver disease, and 63 patients with hemochromatosis). Chronic liver diseases patients other than hemochromatics did not have an increased frequency of HFE gene mutations compared to controls. Although 33.3% of patients with hepatitis B, 43% of patients with hepatitis C, and 73.2% of patients with alcoholic liver disease had elevated transferrin saturation or serum ferritin levels, the presence of HFE gene mutations was not significantly associated with iron overload in these patients. Additionally, patients with cirrhosis did not have

Název v anglickém jazyce

Iron overload and HFE gene mutations in Czech patients with chronic liver diseases

Popis výsledku anglicky

The aim of the study was to identify the prevalence of HFE gene mutations in Czech patients with chronic liver diseases and the influence of the mutations on iron status. The presence of HFE gene mutations (C282Y, H63D, and S65C) analyzed by the PCR-RFLPmethod, presence of cirrhosis, and serum iron indices were compared among 454 patients with different chronic liver diseases (51 with chronic hepatitis B, 122 with chronic hepatitis C, 218 with alcoholic liver disease, and 63 patients with hemochromatosis). Chronic liver diseases patients other than hemochromatics did not have an increased frequency of HFE gene mutations compared to controls. Although 33.3% of patients with hepatitis B, 43% of patients with hepatitis C, and 73.2% of patients with alcoholic liver disease had elevated transferrin saturation or serum ferritin levels, the presence of HFE gene mutations was not significantly associated with iron overload in these patients. Additionally, patients with cirrhosis did not have

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9164" target="_blank" >NR9164: Klinické a funkční koreláty u hypertrofické kardiomyopatie v české populaci</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Disease Markers

ISSN

0278-0240

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

65-72

Kód UT WoS článku

000300107400007

EID výsledku v databázi Scopus

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