Renal Function, Assessed Using Cystatin C, and Antiplatelet Efficacy of Clopidogrel Assessed Using the Vasodilator-Stimulated Phosphoprotein Index in Patients Having Percutaneous Coronary Intervention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A00003820" target="_blank" >RIV/00216208:11120/12:00003820 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/12:#0000098

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.amjcard.2011.10.019" target="_blank" >http://dx.doi.org/10.1016/j.amjcard.2011.10.019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amjcard.2011.10.019" target="_blank" >10.1016/j.amjcard.2011.10.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Renal Function, Assessed Using Cystatin C, and Antiplatelet Efficacy of Clopidogrel Assessed Using the Vasodilator-Stimulated Phosphoprotein Index in Patients Having Percutaneous Coronary Intervention

Popis výsledku v původním jazyce

Renal dysfunction is a strong independent predictor of stent thrombosis. The aim of the present study was to evaluate the strength and direction of the association between kidney function and clopidogrel efficacy. The study group consisted of consecutivepatients (N=275) who underwent stent implantation. Drug efficacy was measured using the vasodilator-stimulated phosphoprotein (VASP) index 20 - 4h after 600mg clopidogrel. Non-response was defined as VASP index >=50%. Renal function was determined usingserum cystatin C. The upper reference levels are: 1.12mg/L for <=65 years and 1.21mg/L for >65 years. Estimated glomerular filtration (eGFR) was calculated using cystatin C. The median value of cystatin C was 1.16 mg/L (25th and 75th percentile, 0.96 and 1.43 mg/L). 47.63% of study population had cystatin C above reference levels. 33.1% of patients were non-responders to clopidogrel. No correlation was found between clopidogrel efficacy assessed using the VASP index and kidney function

Název v anglickém jazyce

Renal Function, Assessed Using Cystatin C, and Antiplatelet Efficacy of Clopidogrel Assessed Using the Vasodilator-Stimulated Phosphoprotein Index in Patients Having Percutaneous Coronary Intervention

Popis výsledku anglicky

Renal dysfunction is a strong independent predictor of stent thrombosis. The aim of the present study was to evaluate the strength and direction of the association between kidney function and clopidogrel efficacy. The study group consisted of consecutivepatients (N=275) who underwent stent implantation. Drug efficacy was measured using the vasodilator-stimulated phosphoprotein (VASP) index 20 - 4h after 600mg clopidogrel. Non-response was defined as VASP index >=50%. Renal function was determined usingserum cystatin C. The upper reference levels are: 1.12mg/L for <=65 years and 1.21mg/L for >65 years. Estimated glomerular filtration (eGFR) was calculated using cystatin C. The median value of cystatin C was 1.16 mg/L (25th and 75th percentile, 0.96 and 1.43 mg/L). 47.63% of study population had cystatin C above reference levels. 33.1% of patients were non-responders to clopidogrel. No correlation was found between clopidogrel efficacy assessed using the VASP index and kidney function

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11506" target="_blank" >NT11506: Perioperační ischemie versus perioperační krvácení při nekardiálních operacích u kardiaků: Studie PRAGUE 14</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Cardiology

ISSN

0002-9149

e-ISSN

—

Svazek periodika

109

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

620-623

Kód UT WoS článku

000301394200004

EID výsledku v databázi Scopus

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