The relationship between S100B protein serum levels, injury severity and Glasgow Outcome Scale values in children with CNS injuries

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906497" target="_blank" >RIV/00216208:11120/12:43906497 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064190:_____/12:#0000414

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The relationship between S100B protein serum levels, injury severity and Glasgow Outcome Scale values in children with CNS injuries

Popis výsledku v původním jazyce

The S100B protein subgroup is a thermolabile acidic calcium-binding protein, which was first described in association with the central nervous system. Destruction of nerve tissue results in S100B protein release from astrocytes and elevation of its levels in cerebrospinal fluid. If the blood-brain barrier is also damaged, S100B can pass into the systemic circulation and elevated blood levels of S100B can be detected. High S100B serum levels in patients with head injuries are predictive of possible development of secondary brain injury and may be related to the extent of permanent injury to the CNS. The authors present results obtained from a group of 39 children aged 0 (newborns) to 17 years with an isolated craniocerebral injury. RESULTS: In our groupof 39 children (aged 0-17 years) we observed excellent GOS group (GOS - Glasgow Outcome Scale 4 or 5) in 33 patients at the time of transfer from our intensive care unit to the neurological department. There were no deaths and only 6 chi

Název v anglickém jazyce

The relationship between S100B protein serum levels, injury severity and Glasgow Outcome Scale values in children with CNS injuries

Popis výsledku anglicky

The S100B protein subgroup is a thermolabile acidic calcium-binding protein, which was first described in association with the central nervous system. Destruction of nerve tissue results in S100B protein release from astrocytes and elevation of its levels in cerebrospinal fluid. If the blood-brain barrier is also damaged, S100B can pass into the systemic circulation and elevated blood levels of S100B can be detected. High S100B serum levels in patients with head injuries are predictive of possible development of secondary brain injury and may be related to the extent of permanent injury to the CNS. The authors present results obtained from a group of 39 children aged 0 (newborns) to 17 years with an isolated craniocerebral injury. RESULTS: In our groupof 39 children (aged 0-17 years) we observed excellent GOS group (GOS - Glasgow Outcome Scale 4 or 5) in 33 patients at the time of transfer from our intensive care unit to the neurological department. There were no deaths and only 6 chi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

5

Strana od-do

207-211

Kód UT WoS článku

000305037700016

EID výsledku v databázi Scopus

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