Regional cerebellar metabolism ((18)FDG PET) predicts the clinical outcome of the short-term inpatient treatment of alcohol addiction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43906587" target="_blank" >RIV/00216208:11120/12:43906587 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/12:43913795

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Regional cerebellar metabolism ((18)FDG PET) predicts the clinical outcome of the short-term inpatient treatment of alcohol addiction

Popis výsledku v původním jazyce

OBJECTIVES: The acute and maintenance treatment of alcohol addiction represents the clinical challenge. The aims of our study were to evaluate the influence of alcohol consumption on regional brain metabolism and the predictive value of PET by means of the duration and quality of remission which followed the sub-acute treatment. METHODS: PET investigation with (18)fluoro-deoxyglucose ((18)FDG) were performed in detoxified patients with alcohol dependence at the end of short-term treatment. Abstinence was evaluated in patients during the one year follow-up period. RESULTS: We detected the positive correlation between (18)FDG uptake in the cerebellar vermis (FWE, p<0.05) and duration of abstinence within one year. DISCUSSION: Our findings support the assumption that the cerebellum would be involved in the maintenance of abstinence in alcohol dependent subjects. Cerebellar connections with cortical areas critical for addiction such as frontal, parietal, temporal regions would mediate the

Název v anglickém jazyce

Regional cerebellar metabolism ((18)FDG PET) predicts the clinical outcome of the short-term inpatient treatment of alcohol addiction

Popis výsledku anglicky

OBJECTIVES: The acute and maintenance treatment of alcohol addiction represents the clinical challenge. The aims of our study were to evaluate the influence of alcohol consumption on regional brain metabolism and the predictive value of PET by means of the duration and quality of remission which followed the sub-acute treatment. METHODS: PET investigation with (18)fluoro-deoxyglucose ((18)FDG) were performed in detoxified patients with alcohol dependence at the end of short-term treatment. Abstinence was evaluated in patients during the one year follow-up period. RESULTS: We detected the positive correlation between (18)FDG uptake in the cerebellar vermis (FWE, p<0.05) and duration of abstinence within one year. DISCUSSION: Our findings support the assumption that the cerebellum would be involved in the maintenance of abstinence in alcohol dependent subjects. Cerebellar connections with cortical areas critical for addiction such as frontal, parietal, temporal regions would mediate the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

—

Projekt

<a href="/cs/project/NS10253" target="_blank" >NS10253: Přetrvávající prefrontální aktivace jako marker cravingu a prediktor ztráty perzistence v léčbě závislosti</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

6

Strana od-do

419-424

Kód UT WoS článku

000310259500011

EID výsledku v databázi Scopus

—