Antidepressant monotherapy compared with combinations of antidepressants in the treatment of resistant depressive patients: A randomized, open-label study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43896091" target="_blank" >RIV/00216208:11120/13:43896091 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023752:_____/13:43914159

Výsledek na webu

<a href="http://dx.doi.org/10.3109/13651501.2012.674533" target="_blank" >http://dx.doi.org/10.3109/13651501.2012.674533</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/13651501.2012.674533" target="_blank" >10.3109/13651501.2012.674533</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Antidepressant monotherapy compared with combinations of antidepressants in the treatment of resistant depressive patients: A randomized, open-label study

Popis výsledku v původním jazyce

This randomized, 6-week, open-label study compared efficacy of CAD and antidepressant monotherapies (ADM) that had been chosen according to clinical judgment of the attending psychiatrist. Methods. A total of 60 inpatients (intent-to-treat analysis) withdepressive disorder (> 1 unsuccessful antidepressant treatment) were randomly assigned to the interventions. The responders who completed the acute phase of study, were evaluated for relapse within 2 months of follow-up treatment. The primary outcome measure was change in the Montgomery-Asberg Depression Rating Scale (MADRS) and response was defined as a > 50% reduction of MADRS score. Results. Mean changes in total MADRS score from baseline to week 6 for patients in both treatment modalities were notdifferent (ADM = 13.2 - 8.6 points; CAD = 14.5 - 9.5 points; P = 0.58). The analysis of covariance performed for significantly higher value of imipramine equivalent dose in CAD group showed only a non-significant between-group difference

Název v anglickém jazyce

Antidepressant monotherapy compared with combinations of antidepressants in the treatment of resistant depressive patients: A randomized, open-label study

Popis výsledku anglicky

This randomized, 6-week, open-label study compared efficacy of CAD and antidepressant monotherapies (ADM) that had been chosen according to clinical judgment of the attending psychiatrist. Methods. A total of 60 inpatients (intent-to-treat analysis) withdepressive disorder (> 1 unsuccessful antidepressant treatment) were randomly assigned to the interventions. The responders who completed the acute phase of study, were evaluated for relapse within 2 months of follow-up treatment. The primary outcome measure was change in the Montgomery-Asberg Depression Rating Scale (MADRS) and response was defined as a > 50% reduction of MADRS score. Results. Mean changes in total MADRS score from baseline to week 6 for patients in both treatment modalities were notdifferent (ADM = 13.2 - 8.6 points; CAD = 14.5 - 9.5 points; P = 0.58). The analysis of covariance performed for significantly higher value of imipramine equivalent dose in CAD group showed only a non-significant between-group difference

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10368" target="_blank" >NS10368: Prospektivní, randomizované hodnocení účinnosti léčby monoterapií antidepresivy a kombinací antidepresiv u pacientů s rezistentní depresivní poruchou.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Psychiatry in Clinical Practice

ISSN

1365-1501

e-ISSN

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Svazek periodika

17

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

35-43

Kód UT WoS článku

000314536800007

EID výsledku v databázi Scopus

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