Mechanism of paracetamol-induced hypotension in critically ill patients: A prospective observational cross-over study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43896918" target="_blank" >RIV/00216208:11120/13:43896918 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.aucc.2012.02.002" target="_blank" >http://dx.doi.org/10.1016/j.aucc.2012.02.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aucc.2012.02.002" target="_blank" >10.1016/j.aucc.2012.02.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanism of paracetamol-induced hypotension in critically ill patients: A prospective observational cross-over study

Popis výsledku v původním jazyce

Objective: To elucidate the mechanism of hypotension following intravenous administration of paracetamol (acetaminophen) to patients on the Intensive Care Unit. Ventilated critically ill patients monitored by PiCCO and administered intravenous paracetamol at the same time were eligible for the study. We recorded haemodynamic indices, as well as core and peripheral temperatures, continuously for 3 h after the dose of paracetamol. Ranitidine was then used as a control drug known not to influence haemodynamics. Results: We included 6 subjects, and recorded 48 cycles of observations after administration of paracetamol, and 35 cycles after administration of the control drug. Haemodynamic parameters were not different at the baseline and administration of control drug did not result in any change in haemodynamics. After intravenous paracetamol, mean arterial pressure (MAP) dropped by 7% (p < 0.001) with a nadir at the 19th minute. In 22 measurement cycles (45%) we noted >15% reduction in MAP

Název v anglickém jazyce

Mechanism of paracetamol-induced hypotension in critically ill patients: A prospective observational cross-over study

Popis výsledku anglicky

Objective: To elucidate the mechanism of hypotension following intravenous administration of paracetamol (acetaminophen) to patients on the Intensive Care Unit. Ventilated critically ill patients monitored by PiCCO and administered intravenous paracetamol at the same time were eligible for the study. We recorded haemodynamic indices, as well as core and peripheral temperatures, continuously for 3 h after the dose of paracetamol. Ranitidine was then used as a control drug known not to influence haemodynamics. Results: We included 6 subjects, and recorded 48 cycles of observations after administration of paracetamol, and 35 cycles after administration of the control drug. Haemodynamic parameters were not different at the baseline and administration of control drug did not result in any change in haemodynamics. After intravenous paracetamol, mean arterial pressure (MAP) dropped by 7% (p < 0.001) with a nadir at the 19th minute. In 22 measurement cycles (45%) we noted >15% reduction in MAP

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Australian Critical Care

ISSN

1036-7314

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

8

Strana od-do

136-141

Kód UT WoS článku

000324821600008

EID výsledku v databázi Scopus

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