Differential effect of baclofen on cortical and spinal inhibitory circuits

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906099" target="_blank" >RIV/00216208:11120/13:43906099 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023884:_____/12:00007614

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clinph.2012.07.005" target="_blank" >http://dx.doi.org/10.1016/j.clinph.2012.07.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2012.07.005" target="_blank" >10.1016/j.clinph.2012.07.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Differential effect of baclofen on cortical and spinal inhibitory circuits

Popis výsledku v původním jazyce

The cutaneous silent period (SP) is a spinal inhibitory reflex, which suppresses activity in spinal motor nuclei. Transcranial magnetic stimulation (TMS) elicits a cortical SP, which represents GABA(B) receptor-mediated inhibition of cortical excitability. Baclofen as a strong GABA(B) agonist effectively reduces muscle hypertonia, however, it is not known whether intrathecal baclofen (ITB) may modulate spinal inhibitory circuits. We evaluated clinical and neurophysiological effects of ITB in ten patients with severe spasticity due to spinal cord injury (n=9) and chronic progressive multiple sclerosis (n=1). Neurophysiological assessment included H reflex and cutaneous and cortical SPs, before and 15, 30, 60, 90, 120, and 180min after ITB bolus administration. RESULTS: ITB suppressed soleus H reflex as early as 15min after lumbar bolus injection; MAS scores declined after 1h. Cortical SP end latency and duration increased progressively with a significant maximum 3h following ITB bolus,

Název v anglickém jazyce

Differential effect of baclofen on cortical and spinal inhibitory circuits

Popis výsledku anglicky

The cutaneous silent period (SP) is a spinal inhibitory reflex, which suppresses activity in spinal motor nuclei. Transcranial magnetic stimulation (TMS) elicits a cortical SP, which represents GABA(B) receptor-mediated inhibition of cortical excitability. Baclofen as a strong GABA(B) agonist effectively reduces muscle hypertonia, however, it is not known whether intrathecal baclofen (ITB) may modulate spinal inhibitory circuits. We evaluated clinical and neurophysiological effects of ITB in ten patients with severe spasticity due to spinal cord injury (n=9) and chronic progressive multiple sclerosis (n=1). Neurophysiological assessment included H reflex and cutaneous and cortical SPs, before and 15, 30, 60, 90, 120, and 180min after ITB bolus administration. RESULTS: ITB suppressed soleus H reflex as early as 15min after lumbar bolus injection; MAS scores declined after 1h. Cortical SP end latency and duration increased progressively with a significant maximum 3h following ITB bolus,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NT12282" target="_blank" >NT12282: Patofyziologické mechanismy neuromodulační léčby u dystonií</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

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Svazek periodika

124

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

7

Strana od-do

339-345

Kód UT WoS článku

000313592400015

EID výsledku v databázi Scopus

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