Pregnancy outcome following maternal exposure to statins: a multicentre prospective study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906553" target="_blank" >RIV/00216208:11120/13:43906553 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/1471-0528.12066" target="_blank" >http://dx.doi.org/10.1111/1471-0528.12066</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1471-0528.12066" target="_blank" >10.1111/1471-0528.12066</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pregnancy outcome following maternal exposure to statins: a multicentre prospective study

Popis výsledku v původním jazyce

This contribution addresses the risk associated with exposure to statins during pregnancy. Design Multicentre observational prospective controlled study. Setting European Network of Teratology Information Services. Population Pregnant women who contactedone of 11 participating centres, seeking advice about exposure to statins during pregnancy, or to agents known to be nonteratogenic. Methods Pregnancies exposed during first trimester to statins were followed up prospectively, and their outcomes were compared with a matched control group. Main outcome measures Rates of major birth defects, live births, miscarriages, elective terminations, preterm deliveries and gestational age and birthweight at delivery. Results We collected observations from 249 exposed pregnancies and 249 controls. The difference in the rate of major birth defects between the statin-exposed and the control groups was small and statistically nonsignificant (4.1% versus 2.7% odds ratio [OR] 1.5; 9! 5% confidence inter

Název v anglickém jazyce

Pregnancy outcome following maternal exposure to statins: a multicentre prospective study

Popis výsledku anglicky

This contribution addresses the risk associated with exposure to statins during pregnancy. Design Multicentre observational prospective controlled study. Setting European Network of Teratology Information Services. Population Pregnant women who contactedone of 11 participating centres, seeking advice about exposure to statins during pregnancy, or to agents known to be nonteratogenic. Methods Pregnancies exposed during first trimester to statins were followed up prospectively, and their outcomes were compared with a matched control group. Main outcome measures Rates of major birth defects, live births, miscarriages, elective terminations, preterm deliveries and gestational age and birthweight at delivery. Results We collected observations from 249 exposed pregnancies and 249 controls. The difference in the rate of major birth defects between the statin-exposed and the control groups was small and statistically nonsignificant (4.1% versus 2.7% odds ratio [OR] 1.5; 9! 5% confidence inter

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

<a href="/cs/project/LA08034" target="_blank" >LA08034: Členství v European Network of Teratology Information Services (ENTIS)</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BJOG - An International Journal of Obstetrics and Gynaecology

ISSN

1470-0328

e-ISSN

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Svazek periodika

120

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

463-471

Kód UT WoS článku

000314975000011

EID výsledku v databázi Scopus

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