The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907252" target="_blank" >RIV/00216208:11120/13:43907252 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/13:#0000351 RIV/00023001:_____/13:00058480

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.transproceed.2012.07.159" target="_blank" >http://dx.doi.org/10.1016/j.transproceed.2012.07.159</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2012.07.159" target="_blank" >10.1016/j.transproceed.2012.07.159</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture

Popis výsledku v původním jazyce

The diagnosis of sepsis is difficult in immunocompromised patients owing to their modified response to infection. Our experiment in minipigs was designed to compare responses to sepsis between experimental groups of septic minipigs with and without immunosuppression. Minipigs with identical baseline parameters were randomized into 3 groups. All CLP animals developed septic shock with a febrile response, tachycardia, and hypotension requiring noradrenaline administration. The hemodynamic responses to sepsis in septic groups with and without immunosuppression were similar. Noradrenaline infusion was started on average later in the immunosuppression than in the group without immunosuppression; however, the difference was not significant. The kinetics of the plasma levels of most selected cytokines and C-reactive protein were similar in both septic groups. All CLP animals developed sepsis within 24 hours on average. Significant differences in IL-6 and IL-10 plasma levels were recorded betw

Název v anglickém jazyce

The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture

Popis výsledku anglicky

The diagnosis of sepsis is difficult in immunocompromised patients owing to their modified response to infection. Our experiment in minipigs was designed to compare responses to sepsis between experimental groups of septic minipigs with and without immunosuppression. Minipigs with identical baseline parameters were randomized into 3 groups. All CLP animals developed septic shock with a febrile response, tachycardia, and hypotension requiring noradrenaline administration. The hemodynamic responses to sepsis in septic groups with and without immunosuppression were similar. Noradrenaline infusion was started on average later in the immunosuppression than in the group without immunosuppression; however, the difference was not significant. The kinetics of the plasma levels of most selected cytokines and C-reactive protein were similar in both septic groups. All CLP animals developed sepsis within 24 hours on average. Significant differences in IL-6 and IL-10 plasma levels were recorded betw

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10556" target="_blank" >NS10556: Vliv imunosuprese na imunopatologické alterace u zvířecího modelu sepse</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation Proceedings

ISSN

0041-1345

e-ISSN

—

Svazek periodika

45

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

770-777

Kód UT WoS článku

000316772500052

EID výsledku v databázi Scopus

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