Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907498" target="_blank" >RIV/00216208:11120/13:43907498 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s00125-013-2931-z" target="_blank" >http://dx.doi.org/10.1007/s00125-013-2931-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00125-013-2931-z" target="_blank" >10.1007/s00125-013-2931-z</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
Popis výsledku v původním jazyce
Alterations in white adipose tissue (WAT) function, including changes in protein (adipokine) secretion and extracellular matrix (ECM) composition, promote an insulin-resistant state. We set out to identify novel adipokines regulated by body fat mass in human subcutaneous WAT with potential roles in adipose function. Adipose transcriptome data and secretome profiles from conditions with increased/decreased WAT mass were combined. WAT donors were predominantly women. In vitro effects were assessed using recombinant protein. Results were confirmed by quantitative PCR/ELISA, metabolic assays and immunochemistry in human WAT and adipocytes. We identified a hitherto uncharacterised adipokine, semaphorin 3C (SEMA3C), the expression of which correlated significantly with body weight, insulin resistance (HOMA of insulin resistance [HOMA(IR)], and the rate constant for the insulin tolerance test [K-ITT]) and adipose tissue morphology (hypertrophy vs hyperplasia). SEMA3C was primarily found in ma
Název v anglickém jazyce
Semaphorin 3C is a novel adipokine linked to extracellular matrix composition
Popis výsledku anglicky
Alterations in white adipose tissue (WAT) function, including changes in protein (adipokine) secretion and extracellular matrix (ECM) composition, promote an insulin-resistant state. We set out to identify novel adipokines regulated by body fat mass in human subcutaneous WAT with potential roles in adipose function. Adipose transcriptome data and secretome profiles from conditions with increased/decreased WAT mass were combined. WAT donors were predominantly women. In vitro effects were assessed using recombinant protein. Results were confirmed by quantitative PCR/ELISA, metabolic assays and immunochemistry in human WAT and adipocytes. We identified a hitherto uncharacterised adipokine, semaphorin 3C (SEMA3C), the expression of which correlated significantly with body weight, insulin resistance (HOMA of insulin resistance [HOMA(IR)], and the rate constant for the insulin tolerance test [K-ITT]) and adipose tissue morphology (hypertrophy vs hyperplasia). SEMA3C was primarily found in ma
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FB - Endokrinologie, diabetologie, metabolismus, výživa
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
R - Projekt Ramcoveho programu EK
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Diabetologia
ISSN
0012-186X
e-ISSN
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Svazek periodika
56
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
10
Strana od-do
1792-1801
Kód UT WoS článku
000321285400015
EID výsledku v databázi Scopus
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