Effect of short-term hyperglycemia on adipose tissue fluxes of selected cytokines in vivo during multiple phases of diet-induced weight loss in obese women
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909502" target="_blank" >RIV/00216208:11120/15:43909502 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00064173:_____/15:#0000516
Výsledek na webu
<a href="http://dx.doi.org/10.1210/jc.2014-3846" target="_blank" >http://dx.doi.org/10.1210/jc.2014-3846</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2014-3846" target="_blank" >10.1210/jc.2014-3846</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of short-term hyperglycemia on adipose tissue fluxes of selected cytokines in vivo during multiple phases of diet-induced weight loss in obese women
Popis výsledku v původním jazyce
Context: Hyperglycemia is suggested to be one of the drivers of the pro-inflammatory state observed in obese and diabetic patients. Objective: To investigate 1) whether subcutaneous abdominal adipose tissue (scAT) could be one of the important sources ofpro-inflammatory cytokines released in response to short-term hyperglycemia and 2) whether this secretion capacity could be influenced by weight loss. Design, Patients, and Interventions: Output of cytokines and proteins of acute phase from scAT in response to a 3 hours' hyperglycemic clamp was evaluated in 9 obese women in vivo using Fick's Principle. Moreover, the output of cytokines was analyzed during a multi-phase dietary intervention consisting of 1 month very-low calorie diet and subsequent 5 months weight stabilization phase. Main Outcome Measure(s): The levels of cytokines and proteins of acute phase (IL-6, IL-8, IL-1Ra, TNF-?, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A and C-reactive protein) in arterial and
Název v anglickém jazyce
Effect of short-term hyperglycemia on adipose tissue fluxes of selected cytokines in vivo during multiple phases of diet-induced weight loss in obese women
Popis výsledku anglicky
Context: Hyperglycemia is suggested to be one of the drivers of the pro-inflammatory state observed in obese and diabetic patients. Objective: To investigate 1) whether subcutaneous abdominal adipose tissue (scAT) could be one of the important sources ofpro-inflammatory cytokines released in response to short-term hyperglycemia and 2) whether this secretion capacity could be influenced by weight loss. Design, Patients, and Interventions: Output of cytokines and proteins of acute phase from scAT in response to a 3 hours' hyperglycemic clamp was evaluated in 9 obese women in vivo using Fick's Principle. Moreover, the output of cytokines was analyzed during a multi-phase dietary intervention consisting of 1 month very-low calorie diet and subsequent 5 months weight stabilization phase. Main Outcome Measure(s): The levels of cytokines and proteins of acute phase (IL-6, IL-8, IL-1Ra, TNF-?, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A and C-reactive protein) in arterial and
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FB - Endokrinologie, diabetologie, metabolismus, výživa
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT14486" target="_blank" >NT14486: Úloha mastných kyselin v regulaci imunitního stavu tukové tkáně</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Clinical Endocrinology & Metabolism
ISSN
0021-972X
e-ISSN
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Svazek periodika
100
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
8
Strana od-do
1949-1956
Kód UT WoS článku
000357669000049
EID výsledku v databázi Scopus
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