Intrathecal baclofen in spinal spasticity: frequency and severity of withdrawal syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909578" target="_blank" >RIV/00216208:11120/15:43909578 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=18&page=E633" target="_blank" >http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=18&page=E633</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Intrathecal baclofen in spinal spasticity: frequency and severity of withdrawal syndrome

Popis výsledku v původním jazyce

BACKGROUND: Intrathecal baclofen (ITB) delivered by programmable pump devices represents an important modality for long-term treatment of severe spinal spasticity. OBJECTIVE: One of the serious adverse events is a withdrawal syndrome after sudden interruption of ITB delivery. In this study, we analyzed the frequency and severity of this complication. Treatment recommendations follow. METHODS: A total of 54 ITB pumps were successfully implanted in 39 patients with severe intractable spasticity (24 with spinal cord injury, 15 with multiple sclerosis, 24 men, age range 21 - 59 years). RESULTS: Eight patients developed a withdrawal syndrome on total a daily dose of ITB between 90 - 420 ?g/day. Seven patients had catheter-related complications. In one patient, pump failure was observed due to its corrosion. Within the group, baclofen withdrawal syndrome occurred once in 20.1 pump-years counted out of 160.4 pump-years of ITB treatment. CONCLUSIONS: ITB withdrawal syndrome is a rare but life-

Název v anglickém jazyce

Intrathecal baclofen in spinal spasticity: frequency and severity of withdrawal syndrome

Popis výsledku anglicky

BACKGROUND: Intrathecal baclofen (ITB) delivered by programmable pump devices represents an important modality for long-term treatment of severe spinal spasticity. OBJECTIVE: One of the serious adverse events is a withdrawal syndrome after sudden interruption of ITB delivery. In this study, we analyzed the frequency and severity of this complication. Treatment recommendations follow. METHODS: A total of 54 ITB pumps were successfully implanted in 39 patients with severe intractable spasticity (24 with spinal cord injury, 15 with multiple sclerosis, 24 men, age range 21 - 59 years). RESULTS: Eight patients developed a withdrawal syndrome on total a daily dose of ITB between 90 - 420 ?g/day. Seven patients had catheter-related complications. In one patient, pump failure was observed due to its corrosion. Within the group, baclofen withdrawal syndrome occurred once in 20.1 pump-years counted out of 160.4 pump-years of ITB treatment. CONCLUSIONS: ITB withdrawal syndrome is a rare but life-

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pain Physician

ISSN

1533-3159

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

"E633"-"E641"

Kód UT WoS článku

000358900300010

EID výsledku v databázi Scopus

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