The effect of prenatal methamphetamine exposure on recognition memory in adult rats
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909641" target="_blank" >RIV/00216208:11120/15:43909641 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00023752:_____/15:43914731
Výsledek na webu
<a href="http://dx.doi.org/10.14712/23362936.2015.43" target="_blank" >http://dx.doi.org/10.14712/23362936.2015.43</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/23362936.2015.43" target="_blank" >10.14712/23362936.2015.43</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The effect of prenatal methamphetamine exposure on recognition memory in adult rats
Popis výsledku v původním jazyce
The use of methamphetamine (MA) among pregnant women is an increasing world-wide health problem. Prenatal MA exposure may cause changes in foetus but the exact effects have remained unclear. The aim of this study is to present the effect of prenatal MA exposure on recognition memory in adult rats. Adult female Wistar rats were injected daily with D-methamphetamine HCl (MA; 5 mg/kg, s.c.) during the entire gestation period. Control females were treated with saline in the same regime. Adult male offspringwas administrated acutely by MA (1 mg/kg i.p.) or saline 30 minutes before beginning of an experiment. For testing recognition memory two tasks were chosen: Novel Object Recognition Test (NORT) and Object Location Test (OLT). Our results demonstrate that prenatally MA-exposed animals were worse in NORT independently on an acute administration of MA in adulthood. Prenatally MA-exposed rats did not deteriorate in OLT, but after acute administration of MA in adulthood, there was significan
Název v anglickém jazyce
The effect of prenatal methamphetamine exposure on recognition memory in adult rats
Popis výsledku anglicky
The use of methamphetamine (MA) among pregnant women is an increasing world-wide health problem. Prenatal MA exposure may cause changes in foetus but the exact effects have remained unclear. The aim of this study is to present the effect of prenatal MA exposure on recognition memory in adult rats. Adult female Wistar rats were injected daily with D-methamphetamine HCl (MA; 5 mg/kg, s.c.) during the entire gestation period. Control females were treated with saline in the same regime. Adult male offspringwas administrated acutely by MA (1 mg/kg i.p.) or saline 30 minutes before beginning of an experiment. For testing recognition memory two tasks were chosen: Novel Object Recognition Test (NORT) and Object Location Test (OLT). Our results demonstrate that prenatally MA-exposed animals were worse in NORT independently on an acute administration of MA in adulthood. Prenatally MA-exposed rats did not deteriorate in OLT, but after acute administration of MA in adulthood, there was significan
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP303%2F10%2F0580" target="_blank" >GAP303/10/0580: Jaká je úloha mesolimbického systému odměny na dlouhodobý účinek prenatální expozice metamfetaminu u laboratorního potkana?</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Prague Medical Report
ISSN
1214-6994
e-ISSN
—
Svazek periodika
116
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
9
Strana od-do
31-39
Kód UT WoS článku
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EID výsledku v databázi Scopus
2-s2.0-84936110075