Can anxiety tested in the Elevated Plus Maze be related to nociception sensitivity in adult male rats?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F16%3A43912349" target="_blank" >RIV/00216208:11120/16:43912349 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.14712/23362936.2016.19" target="_blank" >http://dx.doi.org/10.14712/23362936.2016.19</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/23362936.2016.19" target="_blank" >10.14712/23362936.2016.19</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can anxiety tested in the Elevated Plus Maze be related to nociception sensitivity in adult male rats?

Popis výsledku v původním jazyce

Methamphetamine (MA) is one of the most addictive psychostimulant drugs with a high potential for abuse. Our previous studies demonstrated that MA administered to pregnant rats increases pain sensitivity and anxiety in their adult offspring and makes them more sensitive to acute administration of the same drug in adulthood. Because individuals can differ considerably in terms of behavior and physiology, such as rats that do not belong in some characteristics (e.g. anxiety) to average (the most often incidence), can be described as Low-responders or High-responders, are then more or less sensitive to pain. Therefore, prenatally MA-exposed adult male rats treated in adulthood with a single dose of MA (1 mg/ml/kg) or saline (1 ml/kg) were tested in the present study. We examined the effect of acute MA treatment on: (1) the anxiety in the Elevated Plus-Maze (EPM) test and memory in EPM re-test; (2) nociception sensitivity in the Plantar test; (3) the correlation between the anxiety, memory and the nociception. Our results demonstrate that (1) MA has an anxiogenic effect on animals prenatally exposed to the same drug in the EPM; (2) all the differences induced by acute MA treatment disappeared within the time of 48 hours; (3) there was no effect of MA on nociception per se, but MA induced higher anxiety in individuals less sensitive to pain than in animals more sensitive to pain. In conclusion, the present study shows unique data showing correlation between anxiety and nociceptive sensitivity of prenatally MA-exposed rats that is induced by acute drug administration.

Název v anglickém jazyce

Can anxiety tested in the Elevated Plus Maze be related to nociception sensitivity in adult male rats?

Popis výsledku anglicky

Methamphetamine (MA) is one of the most addictive psychostimulant drugs with a high potential for abuse. Our previous studies demonstrated that MA administered to pregnant rats increases pain sensitivity and anxiety in their adult offspring and makes them more sensitive to acute administration of the same drug in adulthood. Because individuals can differ considerably in terms of behavior and physiology, such as rats that do not belong in some characteristics (e.g. anxiety) to average (the most often incidence), can be described as Low-responders or High-responders, are then more or less sensitive to pain. Therefore, prenatally MA-exposed adult male rats treated in adulthood with a single dose of MA (1 mg/ml/kg) or saline (1 ml/kg) were tested in the present study. We examined the effect of acute MA treatment on: (1) the anxiety in the Elevated Plus-Maze (EPM) test and memory in EPM re-test; (2) nociception sensitivity in the Plantar test; (3) the correlation between the anxiety, memory and the nociception. Our results demonstrate that (1) MA has an anxiogenic effect on animals prenatally exposed to the same drug in the EPM; (2) all the differences induced by acute MA treatment disappeared within the time of 48 hours; (3) there was no effect of MA on nociception per se, but MA induced higher anxiety in individuals less sensitive to pain than in animals more sensitive to pain. In conclusion, the present study shows unique data showing correlation between anxiety and nociceptive sensitivity of prenatally MA-exposed rats that is induced by acute drug administration.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Svazek periodika

117

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

13

Strana od-do

185-197

Kód UT WoS článku

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EID výsledku v databázi Scopus

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