Photo-crosslinked hyaluronic acid coated upconverting nanoparticles
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43912973" target="_blank" >RIV/00216208:11120/17:43912973 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s11051-017-3751-8" target="_blank" >http://dx.doi.org/10.1007/s11051-017-3751-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11051-017-3751-8" target="_blank" >10.1007/s11051-017-3751-8</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Photo-crosslinked hyaluronic acid coated upconverting nanoparticles
Popis výsledku v původním jazyce
Hyaluronic acid (HA)-coated inorganic nanoparticles display enhanced interaction with the CD44 receptors which are overexpressed in many types of cancer cells. Here, we describe a modification of core-shell β-NaY0.80Yb0.18Er0.02F4@NaYF4 nanoparticles (UCNP) by HA derivative bearing photo-reactive groups. UCNP capped with oleic acid were firstly transferred to aqueous phase by an improved protocol using hydrochloric acid or lactic acid treatment. Subsequently, HA bearing furanacryloyl moieties (HA-FU) was adsorbed on the nanoparticle surface and crosslinked by UV irradiation. The crosslinking resulted in stable HA coating, and no polymer desorption was observed. As-prepared UCNP@HA-FU show a hydrodynamic diameter of about 180 nm and are colloidally stable in water and cell culture media. The cellular uptake by normal human fibroblasts and MDA MB-231 cancer cell line was investigated by upconversion luminescence imaging.
Název v anglickém jazyce
Photo-crosslinked hyaluronic acid coated upconverting nanoparticles
Popis výsledku anglicky
Hyaluronic acid (HA)-coated inorganic nanoparticles display enhanced interaction with the CD44 receptors which are overexpressed in many types of cancer cells. Here, we describe a modification of core-shell β-NaY0.80Yb0.18Er0.02F4@NaYF4 nanoparticles (UCNP) by HA derivative bearing photo-reactive groups. UCNP capped with oleic acid were firstly transferred to aqueous phase by an improved protocol using hydrochloric acid or lactic acid treatment. Subsequently, HA bearing furanacryloyl moieties (HA-FU) was adsorbed on the nanoparticle surface and crosslinked by UV irradiation. The crosslinking resulted in stable HA coating, and no polymer desorption was observed. As-prepared UCNP@HA-FU show a hydrodynamic diameter of about 180 nm and are colloidally stable in water and cell culture media. The cellular uptake by normal human fibroblasts and MDA MB-231 cancer cell line was investigated by upconversion luminescence imaging.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
21001 - Nano-materials (production and properties)
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Nanoparticle Research
ISSN
1388-0764
e-ISSN
—
Svazek periodika
19
Číslo periodika v rámci svazku
February
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
12
Strana od-do
"Article 44"
Kód UT WoS článku
000412346200001
EID výsledku v databázi Scopus
2-s2.0-85011818994