Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913343" target="_blank" >RIV/00216208:11120/17:43913343 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064173:_____/17:N0000105

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000475604" target="_blank" >http://dx.doi.org/10.1159/000475604</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000475604" target="_blank" >10.1159/000475604</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Popis výsledku v původním jazyce

Background/Aims: Branched chain amino acids (BCAAs) are known to exert an insulinotropic effect. Whether this effect is mediated by incretins (glucagon like peptide 1 [GLP-1] or glucose-dependent insulinotropic peptide [GIP]) is not known. The aim of this study was to show whether an equivalent dose of BCAA elicits a greater insulin and incretin response when administered orally than intravenously (IV). Methods: Eighteen healthy, male subjects participated in 3 tests: IV application of BCAA solution, oral ingestion of BCAA and placebo in an equivalent dose (30.7 +- 1.1 g). Glucose, insulin, C-peptide, glucagon, GLP-1, GIP, valine, leucine and isoleucine concentrations were measured. Results: Rise in serum BCAA was achieved in both BCAA tests, with incremental areas under the curve (iAUC) being 2.1 times greater for IV BCAA compared with those of the oral BCAA test (p &lt; 0.0001). Oral and IV BCAA induced comparable insulin response greater than placebo (240 min insulin iAUC: oral 3,411 +- 577 vs. IV 2,361 +- 384 vs. placebo 961.2 +- 175 pmol/L, p = 0.0006). Oral BCAA induced higher GLP-1 (p &lt; 0.0001) and GIP response (p &lt; 0.0001) compared with the IV or placebo. Glucose levels declined significantly (p &lt; 0.001) in the same pattern during both BCAA tests with no change in the placebo group. Conclusions: An equivalent dose of BCAA elicited a comparable insulin and greater incretin response when administered orally and not when administered through IV. We conclude that insulinotropic effects of BCAA are partially incretin dependent.

Název v anglickém jazyce

Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Popis výsledku anglicky

Background/Aims: Branched chain amino acids (BCAAs) are known to exert an insulinotropic effect. Whether this effect is mediated by incretins (glucagon like peptide 1 [GLP-1] or glucose-dependent insulinotropic peptide [GIP]) is not known. The aim of this study was to show whether an equivalent dose of BCAA elicits a greater insulin and incretin response when administered orally than intravenously (IV). Methods: Eighteen healthy, male subjects participated in 3 tests: IV application of BCAA solution, oral ingestion of BCAA and placebo in an equivalent dose (30.7 +- 1.1 g). Glucose, insulin, C-peptide, glucagon, GLP-1, GIP, valine, leucine and isoleucine concentrations were measured. Results: Rise in serum BCAA was achieved in both BCAA tests, with incremental areas under the curve (iAUC) being 2.1 times greater for IV BCAA compared with those of the oral BCAA test (p &lt; 0.0001). Oral and IV BCAA induced comparable insulin response greater than placebo (240 min insulin iAUC: oral 3,411 +- 577 vs. IV 2,361 +- 384 vs. placebo 961.2 +- 175 pmol/L, p = 0.0006). Oral BCAA induced higher GLP-1 (p &lt; 0.0001) and GIP response (p &lt; 0.0001) compared with the IV or placebo. Glucose levels declined significantly (p &lt; 0.001) in the same pattern during both BCAA tests with no change in the placebo group. Conclusions: An equivalent dose of BCAA elicited a comparable insulin and greater incretin response when administered orally and not when administered through IV. We conclude that insulinotropic effects of BCAA are partially incretin dependent.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NT14416" target="_blank" >NT14416: Vliv větvených aminokyselin a saturovaných mastných kyselin na rozvoj inzulínové rezistence</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Nutrition &amp; Metabolism

ISSN

0250-6807

e-ISSN

—

Svazek periodika

70

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

293-302

Kód UT WoS článku

000405094100005

EID výsledku v databázi Scopus

2-s2.0-85020450478