Spontaneous Closure of Patent Ductus Arteriosus in Infants <= 1500 g

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913435" target="_blank" >RIV/00216208:11120/17:43913435 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023698:_____/17:N0000022

Výsledek na webu

<a href="http://dx.doi.org/10.1542/peds.2016-4258" target="_blank" >http://dx.doi.org/10.1542/peds.2016-4258</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1542/peds.2016-4258" target="_blank" >10.1542/peds.2016-4258</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spontaneous Closure of Patent Ductus Arteriosus in Infants <= 1500 g

Popis výsledku v původním jazyce

OBJECTIVES: Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical intervention. METHODS: A retrospective cohort study conducted in 2 European level-3 neonatal units. RESULTS: A total of 368 VLBW infants were born within the study period. Two hundred and ninety-seven infants were free of congenital malformations or heart defects and survived to hospital discharge. Out of those, 280 infants received truly conservative PDA management. In 237 (85%) of nontreated infants, the PDA closed before hospital discharge. The Kaplan-Meier model was used to document the incidence proportion of PDA closure over time for different gestational age groups. The median time to ductal closure was 71, 13, 8, and 6 days in &lt;26+0, 26+0 to 27+6, 28+0 to 29+6, and &gt;=30 weeks, respectively. For different birth weight groups, the median was 48, 22, 9, and 8 days in infants weighing &lt;750, 750 to 999, 1000 to 1249, and 1250 to 1500 g, respectively. No statistically significant relationship was found between PDA closure before hospital discharge and neonatal morbidities. CONCLUSIONS: The likelihood of PDA spontaneous closure in VLBW infants is extremely high. We provide in our findings a platform for future placebo-controlled trials focused on the smallest and youngest infants.

Název v anglickém jazyce

Spontaneous Closure of Patent Ductus Arteriosus in Infants <= 1500 g

Popis výsledku anglicky

OBJECTIVES: Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical intervention. METHODS: A retrospective cohort study conducted in 2 European level-3 neonatal units. RESULTS: A total of 368 VLBW infants were born within the study period. Two hundred and ninety-seven infants were free of congenital malformations or heart defects and survived to hospital discharge. Out of those, 280 infants received truly conservative PDA management. In 237 (85%) of nontreated infants, the PDA closed before hospital discharge. The Kaplan-Meier model was used to document the incidence proportion of PDA closure over time for different gestational age groups. The median time to ductal closure was 71, 13, 8, and 6 days in &lt;26+0, 26+0 to 27+6, 28+0 to 29+6, and &gt;=30 weeks, respectively. For different birth weight groups, the median was 48, 22, 9, and 8 days in infants weighing &lt;750, 750 to 999, 1000 to 1249, and 1250 to 1500 g, respectively. No statistically significant relationship was found between PDA closure before hospital discharge and neonatal morbidities. CONCLUSIONS: The likelihood of PDA spontaneous closure in VLBW infants is extremely high. We provide in our findings a platform for future placebo-controlled trials focused on the smallest and youngest infants.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pediatrics

ISSN

0031-4005

e-ISSN

—

Svazek periodika

140

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"Article e20164258"

Kód UT WoS článku

000406659900019

EID výsledku v databázi Scopus

2-s2.0-85026671944