Utilization and Reference Values of Bone Turnover Markers: Osteocalcin and Procollagen Type 1 N-Propeptide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43916323" target="_blank" >RIV/00216208:11120/17:43916323 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1007/978-94-007-7693-7_37" target="_blank" >https://doi.org/10.1007/978-94-007-7693-7_37</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-94-007-7693-7_37" target="_blank" >10.1007/978-94-007-7693-7_37</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Utilization and Reference Values of Bone Turnover Markers: Osteocalcin and Procollagen Type 1 N-Propeptide

Popis výsledku v původním jazyce

All body bones undergo continual remodeling. This process consists of bone resorption and bone formation which are closely coupled actions. Changes in bone tissue are accompanied by changes of biochemical markers. Plasma (and/or urine) concentration of these markers depends on bone resorption/formation activity, i.e., bone turnover rate. Osteocalcin is important noncollagenous protein in bone matrix, synthetized by osteoblasts and osteocytes. It is a good marker of bone turnover. Its undercarboxylated form has a role in regulation of energy metabolism. Osteocalcin is also involved in biosynthesis of testosterone or neurotransmitter production. Procollagen type 1 N-propeptide is a aminoterminal part of procollagen precursor cleaved by proteases during bone formation process. Its serum concentration is significantly related to newly formed collagen. Procollagen type 1 N-propeptide is supposed to be the most reliable biochemical marker of bone formation at present time. Reference values of both laboratory markers for central European population of children and adolescents are presented, and some data about reference intervals in adults from different ethnic groups are mentioned.

Název v anglickém jazyce

Utilization and Reference Values of Bone Turnover Markers: Osteocalcin and Procollagen Type 1 N-Propeptide

Popis výsledku anglicky

All body bones undergo continual remodeling. This process consists of bone resorption and bone formation which are closely coupled actions. Changes in bone tissue are accompanied by changes of biochemical markers. Plasma (and/or urine) concentration of these markers depends on bone resorption/formation activity, i.e., bone turnover rate. Osteocalcin is important noncollagenous protein in bone matrix, synthetized by osteoblasts and osteocytes. It is a good marker of bone turnover. Its undercarboxylated form has a role in regulation of energy metabolism. Osteocalcin is also involved in biosynthesis of testosterone or neurotransmitter production. Procollagen type 1 N-propeptide is a aminoterminal part of procollagen precursor cleaved by proteases during bone formation process. Its serum concentration is significantly related to newly formed collagen. Procollagen type 1 N-propeptide is supposed to be the most reliable biochemical marker of bone formation at present time. Reference values of both laboratory markers for central European population of children and adolescents are presented, and some data about reference intervals in adults from different ethnic groups are mentioned.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30211 - Orthopaedics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Biomarkers in Bone Disease

ISBN

978-94-007-7692-0

Počet stran výsledku

14

Strana od-do

239-252

Počet stran knihy

1185

Název nakladatele

Springer

Místo vydání

Dordrecht

Kód UT WoS kapitoly

—